CD166, Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | CD166, Mouse |
| Clone | REA370 |
| Host Species | Recombinant Human |
| Reactive Species | mouse |
| Isotype | IgG1 |
| Format | biotin conjugate |
| Size | 30 µg in 1 mL |
| Concentration | 1:10 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD166 Antibody, anti-mouse, Biotin, REAfinity™. Clone REA370 recognizes the mouse CD166 antigen, a Single-pass type I membrane protein also known as Activated leukocyte cell adhesion molecule (ALCAM). CD166 is a member of the immunoglobulin gene superfamily which is expressed by activated leukocytes and thymic epithelial cells and is a ligand for the lymphocyte antigen CD6. It is also expressed at high levels in the brain and lung, at lower levels in the liver and the kidney, and on a number of cell lines. CD166 expression is pathologically correlated with aggressive disease in a variety of cancers including melanoma, prostate, breast, ovarian, esophageal, and bladder cancers. It is also a universal functional marker of murine and human hematopoietic stem cells (HSC) and osteoblasts within the hematopoietic niche and it is involved in modulating HSC-niche interactions and HSC fate. | Additional information: Clone REA370 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | ALCAM, BEN, DM-GRASP, MuSC, SC1 |
| Gene, Accession # | Gene ID: 11658 |
| Catalog # | 130-105-445 |
| Price | $57 |
| Order / More Info | CD166, Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Bowen, M. A. et al. (1997) Characterization of mouse ALCAM (CD166): the CD6-binding domain is conserved in different homologs and mediates cross-species binding. Eur. J. Immunol. 27 (6): 1469-1478. | Chitteti, B. R. et al. (2013) CD166 and regulation of hematopoiesis. Curr. Opin. Hematol. 20 (4): 273-280. | Levin, T. G. et al. (2010) Characterization of the intestinal cancer stem cell marker CD166 in the human and mouse gastrointestinal tract. Gastroenterology 139 (6): 2072-2082. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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