HLA Class I B8, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | HLA Class I B8, Human |
| Clone | REA145 |
| Host Species | Recombinant Human |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | PerCP-Vio 700 conjugate |
| Size | 30 tests in 300 µL |
| Concentration | 1:11 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | HLA Class I B8 Antibody, anti-human, PerCP-Vio® 700, REAfinity™. Clone REA145 recognizes HLA B8, a class I human leukocyte antigen (HLA). Expressed on the surface of most nucleated cells, class I molecules are heterodimeric molecules and consist of a type I integral membrane α heavy chain and soluble β2 microglobulin protein. The extracellular region of the heavy chain further consists of three domains, of which one comprises the peptide binding groove. Antigens binding to class I molecules are 8-10 amino acids long and play an important role in recognition of the virus infected and malignant cells by cytotoxic T lymphocytes (CTLs). In addition, class I molecules interact with NK cell receptors to modulate the activity of NK cells. | Additional information: Clone REA145 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | HLA-B, AS, SPDA1 |
| Gene, Accession # | Gene ID: 3106 |
| Catalog # | 130-099-600 |
| Price | $158 |
| Order / More Info | HLA Class I B8, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Jahnsen, F. L. et al. (2018) Transcriptional and functional profiling defines human small intestinal macrophage subsets. J. Exp. Med. 215 (2): 441-458. | Hewitt, E. W. et al. (2003) The MHC class I antigen presentation pathway: strategies for viral immune evasion. Immunology 110 (2): 163-169. | Edvardsen, K. et al. (2016) Analysis of cellular and humoral immune responses against cytomegalovirus in patients with autoimmune Addison's disease. J. Transl. Med. 14: 68. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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