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Antigenic Specificity | Mcl-1 pS159, Human/Mouse |
Clone | REA924 |
Host Species | Recombinant Human |
Reactive Species | human, mouse |
Isotype | IgG1 |
Format | phycoerythrin (PE) conjugate |
Size | 30 tests in 60 µL |
Concentration | 1:50 |
Applications | Intracellular flow cytometry |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Mcl-1 pS159 Antibody, anti-human/mouse, PE, REAfinity™. Clone REA924 recognizes the human and mouse protein Mcl-1 phosphorylated at serine 159 (pS159). Myeloid cell leukemia-1 (Mcl-1), also known as BCL2L3, is a member of the Bcl-2 family of regulator proteins, which play an important role in the regulation of apoptosis. The two isoforms of Mcl-1 regulate cell survival and apoptosis by inhibiting apoptosis and promotion of apoptosis and death-inducing. Mcl-1 is primarily found in the outer membrane of mitochondria and mainly expressed in programmed myeloid cell differentiation. | Additional information: Clone REA924 displays negligible binding to Fc receptors. |
Immunogen | n/a |
Other Names | MCL1BCL2L3, Bcl2-L-3, Bcl-2-like protein 3, Bcl-2-related protein EAT/mcl1 |
Gene, Accession # | Gene ID: 4170, 17210 |
Catalog # | 130-115-413 |
Price | $119 |
Order / More Info | Mcl-1 pS159, Human/Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG |
Product Specific References | Kozopas, K. M. et al. (1993) MCL1, a gene expressed in programmed myeloid cell differentiation, has sequence similarity to BCL2. Proc. Natl. Acad. Sci. U.S.A. 90 (8): 3516-3520. | Chao, J. R. et al. (1998) mcl-1 is an immediate-early gene activated by the granulocyte-macrophage colony-stimulating factor (GM-CSF) signaling pathway and is one component of the GM-CSF viability response. Mol. Cell. Biol. 18 (8): 4883-4898. | Bingle, C. D. et al. (2000) Exon skipping in Mcl-1 results in a bcl-2 homology domain 3 only gene product that promotes cell death. J. Biol. Chem. 275 (29): 22136-22146. | Maurer, U. et al. (2006) Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1. Mol. Cell 21 (6): 749-760. |