BATF, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | BATF, Human |
| Clone | REA486 |
| Host Species | Recombinant Human |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | allophycocyanin (APC) conjugate |
| Size | 100 tests in 1 mL |
| Concentration | 1:11 |
| Applications | MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | BATF Antibody, anti-human, APC, REAfinity™. Clone REA486 recognizes the human B cell-activating transcription factor (BATF) antigen, a 14 kDa transcription factor belonging to the AP-1 family of basic leucine zipper transcription factors. BATF plays an important role in regulating differentiation and function in many lymphocyte lineages. In the CD8+ T cell lineage, increased expression of BATF in exhausted CD8+ T cells suppresses their effector function. In the CD4+ T cell lineage, BATF is required for the differentiation of interleukin 17 producing helper T cells, where it binds cooperatively with the transcription factor IRF4 and its dimerization partners c-Jun, JunB, and JunD. BATF is also important for the development of follicular helper T cells by regulating the transcription factors Bcl-6 and c-Maf. In addition, BATF is required for class-switch recombination in B cells and to regulate activation-induced cytidine deaminase as well as DNA damage checkpoint in hematopoietic stem cell self-renewal. | Additional information: Clone REA486 displays negligible binding to Fc receptors. | |
| Immunogen | n/a |
| Other Names | B-ATF1, SFA-2, SFA2, B-ATF |
| Gene, Accession # | Gene ID: 10538 |
| Catalog # | 130-107-620 |
| Price | $325 |
| Order / More Info | BATF, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Li, P. et al. (2012) BATF-JUN is critical for IRF4-mediated transcription in T cells. Nature 490 (7421): 543-546. | Kurachi, M. et al. (2014) The transcription factor BATF operates as an essential differentiation checkpoint in early effector CD8+ T cells. Nat Immunol 15 (4): 373-383. | Dorsey, M. J. et al. (1995) B-ATF: a novel human bZIP protein that associates with members of the AP-1 transcription factor family. Oncogene 11 (11): 2255-2265. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
Profile of MILTENYI BIOTEC B.V. & Co. KG