LT-βR, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | LT-βR, Human |
| Clone | REA412 |
| Host Species | Recombinant Human |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | phycoerythrin (PE) conjugate |
| Size | 100 tests in 1 mL |
| Concentration | 1:11 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | LT-βR Antibody, anti-human, PE, REAfinity™. Clone REA412 recognizes the human lymphotoxin beta receptor (LT-βR) antigen, a 47 kDa single-pass type I membrane protein which is also known as tumor necrosis factor receptor superfamily member 3 (TNF-RIII). LT-βR is a member of the TNF receptor family that play a role in the development and organization of lymphoid tissues. Unlike the other TNF receptors, LT-βR does not bind a soluble ligand, but rather, a membrane form of a heterotrimeric lymphotoxin complex comprised of one LTα and two LTβ molecules. The development of lymph nodes is a process that involves the LT-βR dependent crosstalk between mesenchymal lymphoid tissue organizer and hematopoietic lymphoid tissue inducer cells. Cell death induced by LT-βR is dependent on TRAF3, whereas NFκB activation appears to be mediated by TRAF5 or TRAF2. LT-βR is expressed on a variety of human primary and transformed cells, but is absent on T or B lymphocytes and primary monocytes or peripheral dendritic cells, although LT-βR is detected on some myeloid leukemic lines. In the developing thymus LT-βR is prominent along the trabeculae and into the medulla up to corticomedullary junction. In the spleen, LT-βR is prominently expressed by cells in the red pulp and along the borders of red and white pulp which colocalizes with reticular stromal cells. | Additional information: Clone REA412 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | TNF-RIII, LTBR, D12S370, LT-BETA-R, TNF-RII, CD18, TNFR-RP, TNFR2-RP, TNFR3, TNFCR |
| Gene, Accession # | Gene ID: 4055 |
| Catalog # | 130-106-690 |
| Price | $305 |
| Order / More Info | LT-βR, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Onder, L. et al. (2013) Endothelial cell-specific lymphotoxin-β receptor signaling is critical for lymph node and high endothelial venule formation. J. Exp. Med. 210 (3): 465-473. | Crowe, P. D. et al. (1994) A lymphotoxin-beta-specific receptor. Science 264 (5159): 707-710. | Rooney, I. A. et al. (2000) The lymphotoxin-beta receptor is necessary and sufficient for LIGHT-mediated apoptosis of tumor cells. J. Biol. Chem. 275 (19): 14307-14315. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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