CD141 (BDCA-3), Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | CD141 (BDCA-3), Mouse |
| Clone | REA964 |
| Host Species | Recombinant Human |
| Reactive Species | mouse |
| Isotype | IgG1 |
| Format | biotin conjugate |
| Size | 150 µg in 1 mL |
| Concentration | 1:50 |
| Applications | Flow cytometry, MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD141 (BDCA-3) Antibody, anti-mouse, Biotin, REAfinity™. Clone REA964 recognizes the mouse CD141 antigen, which is also known as BDCA-3, thrombomodulin, or fetomodulin. CD141 is a type I cell surface glycoprotein expressed mainly on endothelial cells. CD141 functions as a specific endothelial cell receptor for thrombin. This complex cleaves protein C and the thrombin activatable fibrinolysis Inhibitor (TAFI), initiating an anticoagulant pathway. | Additional information: Clone REA964 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | Thrombomodulin, Fetomodulin, TM, BDCA-3 |
| Gene, Accession # | Gene ID: 21824 |
| Catalog # | 130-116-017 |
| Price | $200 |
| Order / More Info | CD141 (BDCA-3), Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Dittman, W. A. et al. (1988) The structure and function of mouse thrombomodulin. Phorbol myristate acetate stimulates degradation and synthesis of thrombomodulin without affecting mRNA levels in hemangioma cells. J. Biol. Chem. 263 (30): 15815-15822. | Bajzar, L. et al. (1996) TAFI, or plasma procarboxypeptidase B, couples the coagulation and fibrinolytic cascades through the thrombin-thrombomodulin complex. J. Biol. Chem. 271 (28): 16603-16608. | Isermann, B. et al. (2001) Endothelium-specific loss of murine thrombomodulin disrupts the protein C anticoagulant pathway and causes juvenile-onset thrombosis. J. Clin. Invest. 108 (4): 537-546. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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