CD59a, Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | CD59a, Mouse |
| Clone | REA287 |
| Host Species | Recombinant Human |
| Reactive Species | mouse |
| Isotype | IgG1 |
| Format | allophycocyanin (APC) conjugate |
| Size | 30 µg in 1 mL |
| Concentration | 1:10 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD59a Antibody, anti-mouse, APC, REAfinity™. Clone REA287 recognizes the CD59a antigen, the murine analog of human CD59 which is also known as MAC-inhibitory protein (MAC-IP) or membrane attack complex inhibition factor (MACIF). CD59a is widely distributed, being present on all circulating cells, epithelia, and endothelia and in most tissues examined. CD59a blocks the formation of the membrane attack complex of complement by inhibiting binding of C9 to the C5b-8 complex, hereby protecting the cells from complement-mediated lysis. Further, CD59a down-modulates CD4+ T cell activity in vitro and in vivo, thereby revealing another link between complement regulators and T cell activation. | Additional information: Clone REA287 displays negligible binding to Fc receptors. | |
| Immunogen | n/a |
| Other Names | MAC-inhibitory protein (MAC-IP), Membrane attack complex inhibition factor (MACIF), Protectin, CD59 |
| Gene, Accession # | Gene ID: 12509 |
| Catalog # | 130-104-104 |
| Price | $89 |
| Order / More Info | CD59a, Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Longhi, M. P. et al. (2005) Cutting edge: murine CD59a modulates antiviral CD4+ T cell activity in a complement-independent manner. J Immunol 175 (11): 7098-7102. | Powell, M. B. et al. (1997) Molecular cloning, chromosomal localization, expression, and functional characterization of the mouse analogue of human CD59. J Immunol 158 (4): 1692-1702. | Harhausen, D. et al. (2010) Membrane attack complex inhibitor CD59a protects against focal cerebral ischemia in mice. J. Neuroinflammation 4 (7): 15. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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