β-Catenin, Human/Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | β-Catenin, Human/Mouse |
| Clone | REA480 |
| Host Species | Recombinant Human |
| Reactive Species | human, mouse |
| Isotype | IgG1 |
| Format | allophycocyanin (APC) conjugate |
| Size | 100 tests in 200 µL |
| Concentration | 1:50 |
| Applications | 3D-Immunofluorescence, Immunohistochemistry, Immunofluorescence |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | β-Catenin Antibody, anti-human/mouse, APC, REAfinity™. Clone REA480 recognizes the human and mouse β-catenin antigen, a 92 kDa dual function protein regulating the coordination of cell-cell adhesion and gene transcription. β-catenin is a subunit of the cadherin protein complex and acts as an intracellular signal transducer in the Wnt signaling pathway. As a component of adherens junctions, β-catenin binds cadherins, Tcf family transcription factors, and the tumor suppressor adenomatous polyposis coli (APC). Mutations and overexpression of β-catenin are associated with many cancers, including hepatocellular carcinoma, colorectal carcinoma, lung cancer, malignant breast tumors as well as ovarian and endometrial cancer. | Additional information: Clone REA480 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | CTNNB1, CTNNB, MRD19, armadillo, CTNB1, Beta-catenin, Catnb |
| Gene, Accession # | Gene ID: 1499, 12387 |
| Catalog # | 130-124-444 |
| Price | $325 |
| Order / More Info | β-Catenin, Human/Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Butz, S. et al. (1992) Plakoglobin and beta-catenin: distinct but closely related. Science 257 (5073): 1142-1144. | Clevers, H. et al. (2012) Wnt/β-catenin signaling and disease. Cell 149 (6): 1192-1205. | MacDonald, B. T. et al. (2009) Wnt/beta-catenin signaling: components, mechanisms, and diseases. Dev. Cell 17 (1): 9-26. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
Profile of MILTENYI BIOTEC B.V. & Co. KG