CD226 (DNAM-1), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | CD226 (DNAM-1), Human |
| Clone | DX11 |
| Host Species | Mouse |
| Reactive Species | human, nonhuman primate |
| Isotype | IgG1κ |
| Format | purified |
| Size | 100 µg in 1 mL |
| Concentration | n/a |
| Applications | Flow cytometry, MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD226 (DNAM-1) Antibody, anti-human, pure. Clone DX11 recognizes CD226 (DNAM-1), a 65 kDa transmembrane glycoprotein expressed on T cells, natural killer (NK) cells, platelets, monocytes, and a subset of B cells. It is also expressed by a subset of CD3+ thymocytes. The surface association of CD226 (DNAM-1) with LFA-1 on NK cells and T cells permits the transduction of cytolytic signals upon binding of CD226 (DNAM-1) to its ligands CD155 (PVR) and CD112 (Nectin-2). |
| Immunogen | n/a |
| Other Names | DNAM-1, PTA-1, TLiSA1 |
| Gene, Accession # | Gene ID: 10666 |
| Catalog # | 130-092-479 |
| Price | $160 |
| Order / More Info | CD226 (DNAM-1), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Shibuya, A. et al. (1996) DNAM-1, a novel adhesion molecule involved in the cytolytic function of T lymphocytes. Immunity 4: 573-581. | Pende, D. et al. (2005) Analysis of the receptor-ligand interactions in the natural killer-mediated lysis of freshly isolated myeloid or lymphoblastic leukemias: evidence for the involvement of the poliovirus receptor (CD155) and Nectin-2 (CD112). Blood 105: 2066-2073. | Bottino, C. et al. (2003) Identification of PVR (CD155) and Nectin-2 (CD112) as cell surface ligands for the human DNAM-1 (CD226) activating molecule. J. Exp. Med. 198: 557-567. | Moretta, L. and Moretta, A. (2004) Unravelling natural killer function: Triggering and inhibitory human NK receptors. EMBO J. 23: 255-259. | Castriconi, R. et al. (2004) Natural killer cell-mediated killing of freshly isolated neuroblastoma cells: critical role of DNAX accesory molecule-1-poliovirus receptor interaction. Cancer Res. 64: 9180-9184. | Kojima, H. et al. (2003) CD226 mediates platelet and megakaryocytic cell adhesion to vascular endothelial cells. J. Biol. Chem. 278: 36748-36753. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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