CD307b (FcRL2), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | CD307b (FcRL2), Human |
| Clone | REA474 |
| Host Species | Recombinant Human |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | biotin conjugate |
| Size | 30 tests in 300 µL |
| Concentration | 1:11 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD307b (FcRL2) Antibody, anti-human, Biotin, REAfinity™. Clone REA474 recognizes the human CD307b antigen, a single-pass type I membrane protein, which is also known as Fc receptor-like protein 2 (FcRL2) or immunoglobulin receptor translocation-associated protein 4 (IRTA4). CD307b is a protein with immunomodulatory potential that is preferentially expressed by memory B cells in humans. It has two consensus ITIMs in addition to a putative ITAM sequence in its cytoplasmic domain. Coligation of CD307b with the B cell receptor (BCR) leads to tyrosine phosphorylation of its ITIM motifs and subsequent Src homology region 2 domain-containing phosphatase-1 recruitment to facilitate inhibition of BCR signaling. Mutational analysis indicates that the tyrosine residues in both inhibitory motifs of CD307b are required for complete inhibition of BCR signaling, whereas tyrosines in the putative activation motif are dispensable for signal modulation. These findings suggest a negative immunomodulatory function for CD307b in the regulation of memory B cells. | Additional information: Clone REA474 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | FCRL2, FcRH2, IFGP4, IRTA4, SPAP1, SPAP1A, SPAP1B, SPAP1C |
| Gene, Accession # | Gene ID: 79368 |
| Catalog # | 130-107-491 |
| Price | $99 |
| Order / More Info | CD307b (FcRL2), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Jackson, T. A. et al. (2010) FcR-like 2 inhibition of B cell receptor-mediated activation of B cells. J Immunol 185 (12): 7405-7412. | Davis, R. S. et al. (2001) Identification of a family of Fc receptor homologs with preferential B cell expression. Proc. Natl. Acad. Sci. U.S.A. 98 (17): 9772-9777. | Shabani, M. et al. (2014) Ligation of human Fc receptor like-2 by monoclonal antibodies down-regulates B-cell receptor-mediated signalling. Immunology 143 (3): 341-353. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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