TIM-3, Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | TIM-3, Mouse |
| Clone | RMT3-23 |
| Host Species | Rat |
| Reactive Species | mouse |
| Isotype | IgG2aκ |
| Format | phycoerythrin (PE) conjugate |
| Size | 30 µg in 1 mL |
| Concentration | 1:10 |
| Applications | Flow cytometry, MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | TIM-3 Antibody, anti-mouse, PE. The monoclonal antibody RMT3-23 reacts with mouse TIM-3, which is a Th-1-specific cell surface protein expressed by differentiated CD4+ Th1 and CD8+ Tc1 cells and macrophages. It is absent on CD4+ Th2 and CD8+ Tc2 cells. TIM-3 has been proposed to inhibit Th1-mediated immune responses. TIM-3 absence enhances the severity of experimental autoimmune encephalomyelitis in mice. The interaction of TIM-3 and Galectin-9 induces apoptosis of Th1 cells. |
| Immunogen | n/a |
| Other Names | HAVCR2, TIMD-3, Tim3 |
| Gene, Accession # | Gene ID: 171285 |
| Catalog # | 130-102-415 |
| Price | $71 |
| Order / More Info | TIM-3, Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Monney, L. et al. (2002) T?1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease. Nature 415: 536-541. | van de Weyer, P. S. et al. (2006) A highly conserved tyrosine of Tim-3 is phosphorylated upon stimulation by its ligand galectin-9. Biochem. Biophys. Res. Commun. 351 (2): 571-576. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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