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Antigenic Specificity | CD120a (TNF-RI), Human |
Clone | REA252 |
Host Species | Recombinant Human |
Reactive Species | human |
Isotype | IgG1 |
Format | biotin conjugate |
Size | 100 tests in 1 mL |
Concentration | 1:11 |
Applications | Flow cytometry, MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | CD120a (TNF-RI) Antibody, anti-human, Biotin, REAfinity™. Clone REA252 recognizes the extracellular part of the membrane-bound and soluble form of the CD120a antigen, a 55 kDa type I transmembrane glycoprotein also known as tumor necrosis factor receptor type I (TNF-RI) or p55. CD120a belongs to the TNF receptor superfamily and is mainly expressed by monocytes, macrophages, and neutrophils. It is also expressed by a variety of cell lines, tumor cells, and normal cell types including T cells, endothelial cells, hepatocytes, chondrocytes, and fibroblasts. Binding of TNF-α to its main receptor CD120a triggers signaling which is extremely complex, leading to both cell death and survival signals. Sustained activation of TNF signaling has been implicated in the pathogenesis of a wide spectrum of human diseases, including cancer, osteoporosis, sepsis, diabetes, and autoimmune diseases such as multiple sclerosis, rheumatoid arthritis, and inflammatory bowel disease. | Additional information: Clone REA252 displays negligible binding to Fc receptors. |
Immunogen | n/a |
Other Names | TNFRSF1A, FPF, MS5, TBP1, p55, p60, TNF-R1 |
Gene, Accession # | Gene ID: 7132 |
Catalog # | 130-106-284 |
Price | $264 |
Order / More Info | CD120a (TNF-RI), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
Product Specific References | Grell, M. et al. (1998) The type 1 receptor (CD120a) is the high-affinity receptor for soluble tumor necrosis factor. Proc. Natl. Acad. Sci. U.S.A. 95: 570-575. | Bianchi, K. et al. (2009) A tangled web of ubiquitin chains: breaking news in TNF-R1 signaling. Mol. Cell 36 (5): 736-742. | Hijdra, D. et al. (2012) Differential expression of TNFR1 (CD120a) and TNFR2 (CD120b) on subpopulations of human monocytes. J. Inflamm. 9 (1): 38. |