PLC-γ2 pY759, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | PLC-γ2 pY759, Human |
| Clone | REA341 |
| Host Species | Recombinant Human |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | allophycocyanin (APC) conjugate |
| Size | 30 tests in 300 µL |
| Concentration | 1:11 |
| Applications | Intracellular flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | PLC-γ2 pY759 Antibody, anti-human, APC, REAfinity™. Clone REA341 recognizes the phosphoinositide phospholipase C-gamma-2 (PLC-γ2) antigen phosphorylated at tyrosine 759 (pY759). PLC-γ isoforms are mainly regulated through receptors with intrinsic tyrosine kinase activity (e.g. growth factor receptors) or receptors (such as B and T cell antigen receptors) that are linked to the activation of nonreceptor tyrosine kinases through a complex signaling network. The two isoforms of PLC-γ have distinct tissue distributions. Whereas PLC-γ1 is expressed ubiquitously, the pattern of expression of PLC-γ2 is characterized by high levels in cells of hematopoietic origin. PLC-γ2 is a transmembrane signaling enzyme that catalyzes the conversion of phosphatidyl inositol biphosphate to inositol triphosphate (IP3) and diacylglycerol (DAG) using calcium as a cofactor. It has been implicated in collagen-induced signal transduction in platelets and antigen-dependent signaling in B-lymphocytes. PLC-γ2 is regulated through activation of tyrosine kinase-linked receptors. Phosphorylation of PLC-γ2 at tyrosines 753 and 759 leads to activation of the enzyme. Homozygous disruption of PLC-γ2 results in functional and signaling disorders in a subset of cell types including B cells, platelets, and mast cells. | Additional information: Clone REA341 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | PLCG2, APLAID, FCAS3, PLC-IV, PLC-gamma-2 |
| Gene, Accession # | Gene ID: 5336 |
| Catalog # | 130-105-023 |
| Price | $142 |
| Order / More Info | PLC-γ2 pY759, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Ombrello, M. J. et al. (2012) Cold urticaria, immunodeficiency, and autoimmunity related to PLCG2 deletions. N. Engl. J. Med. 366 (4): 330-338. | Rodriguez, R. et al. (2001) Tyrosine residues in phospholipase Cgamma 2 essential for the enzyme function in B-cell signaling. J. Biol. Chem. 276 (51): 47982-47992. | Ozdener, F. et al. (2002) Activation of phospholipase Cgamma2 by tyrosine phosphorylation. Mol. Pharmacol. 62 (3): 672-679. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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