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Antigenic Specificity | CD84, Human |
Clone | MZ18-21F6 |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgG1κ |
Format | phycoerythrin (PE) conjugate |
Size | 100 tests in 1 mL |
Concentration | 1:11 |
Applications | Flow cytometry |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | CD84 Antibody, anti-human, PE. Human CD84 is a 65-80 kDa single-chain surface glycoprotein and member of the CD2 subset of the immunoglobulin (Ig) superfamily. CD84 is expressed on granulocytes, monocytes, macrophages, B cells, platelets, antigen-presenting cells, and subsets of T cells including thymocytes and mature T cells. Homophilic ligation of CD84 or ligation with CD84 antibodies has been shown to lead to enhanced proliferation of T cells as well as IFN-γ secretion. CD84 thus serves as a co-stimulatory molecule. CD84 gene expression has also been detected in lung and kidney tissue as well as on hematopoietic progenitor cells in bone marrow. |
Immunogen | n/a |
Other Names | Ly9b, SLAMF5, hCD84, mCD84, GR6 |
Gene, Accession # | Gene ID: 8832 |
Catalog # | 130-093-277 |
Price | $310 |
Order / More Info | CD84, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
Product Specific References | Martin, M. et al. (2001) CD84 functions as a homophilic adhesion molecule and enhances IFN-γ secretion: adhesion is mediated by Ig-like domain 1. J Immunol 167: 3668-3676. | Tangye, S. G. et al. (2003) Functional requirements for interactions between CD84 and Src homology 2 domain-containing proteins and their contribution to human T cell activation. J Immunol 171: 2485-2495. | Zaiss, M. et al. (2003) CD84 expression on human hematopoietic progenitor cells. Exp. Hematol. 31: 798-805. | de la Fuente, M. A. et al. (1997) CD84 leukocyte antigen is a new member of the Ig superfamily. Blood 90: 2398-2405. | Romero, X. et al. (2004) Differential expression of SAP and EAT-2-binding leukocyte cell-surface molecules CD84, CD150 (SLAM), CD229 (Ly9) and CD244 (2B4). Tissue Antigens 64 (2): 132-144. |