CD270 (HVEM), Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG

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Antigenic SpecificityCD270 (HVEM), Mouse
CloneREA275
Host SpeciesRecombinant Human
Reactive Speciesmouse
IsotypeIgG1
Formatallophycocyanin (APC) conjugate
Size9 µg in 300 µL
Concentration1:10
ApplicationsFlow cytometry, MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry
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DescriptionCD270 (HVEM) Antibody, anti-mouse, APC, REAfinity™. Clone REA275 recognizes the CD270 antigen, a type I transmembrane protein of the TNF-receptor superfamily which is also known as Herpes virus entry mediator (HVEM) or tumor necrosis factor receptor like 2 (TR2). CD270 is expressed in multiple tissues and cell lines and shows a constitutive and relatively high expression in peripheral blood T cells, B cells, monocytes, neutrophils and dendritic cells. Both human and mouse forms of CD270 can mediate entry of herpes simplex virus-1 and -2 (HSV-1 and HSV-2). CD270 transmits both activating and inhibitory signals; e.g interaction with receptors such as BTLA or CD160 attenuates TCR-mediated signaling, whereas interaction with receptor LIGHT allows co-stimulation of T and B cells. | Additional information: Clone REA275 displays negligible binding to Fc receptors. |
Immunogenn/a
Other NamesTNFRSF14, ATAR, HVEA, HVEM, Tnfrs14
Gene, Accession #Gene ID: 230979
Catalog #130-103-411
Price$59
Order / More InfoCD270 (HVEM), Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG
Product Specific ReferencesHsu, H. et al. (1997) ATAR, a novel tumor necrosis factor receptor family member, signal through TRAF2 and TRAF5. J. Biol. Chem. 272: 13471-13474. | Kwon, B. S. et al. (1997) A newly identified member of the tumor necrosis factor receptor superfamily with a wide tissue distribution and involvement in lymphocyte activation. J. Biol. Chem. 272: 14272-14276. | Kim, W. K. et al. (2012) Absence of herpes virus entry mediator (HVEM) increases bone mass by attenuating receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclastogenesis. Endocrinology 153 (10): 4808-4817.
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-Straße 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197

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