CD275 (B7-H2), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | CD275 (B7-H2), Human |
| Clone | REA991 |
| Host Species | Recombinant Human |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | Vio Bright B515 conjugate |
| Size | 100 tests in 200 µL |
| Concentration | 1:50 |
| Applications | Flow cytometry, MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD275 (B7-H2) Antibody, anti-human, Vio® Bright B515, REAfinity™. Clone REA991 recognizes the human CD275 antigen, also known as B7-H2, ICOSL, or GL50, a member of the B7 family of co-stimulatory molecules involved in regulating T cell activation and effector functions. It belongs to the Ig superfamily and has a predicted molecular weight of 40 kDa. CD275 is a ligand of inducible co-stimulator (ICOS) expressed on activated T cells. ICOS mediated co-stimulation promotes T helper (T?) cell differentiation via T?2 cytokine production such as interleukin 10 (IL-10) and IL-4. Human CD275 is expressed on B cells, dendritic cells, endothelial cells, renal tubular epithelial cells, activated monocytes, and human airway epithelial cells. | Additional information: Clone REA991 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | ICOSLG, B7-H2, B7H2, B7RP-1, GL50, ICOSL, LICOS |
| Gene, Accession # | Gene ID: 23308 |
| Catalog # | 130-116-807 |
| Price | $470 |
| Order / More Info | CD275 (B7-H2), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Wang, S. et al. (2000) Costimulation of T cells by B7-H2, a B7-like molecule that binds ICOS. Blood 96 (8): 2808-2813. | Qian, X. et al. (2006) The ICOS-ligand B7-H2, expessed on human type II alveolar epithelial cells, plays a role in the pulmonary host defense system. Eur. J. Immunol. 36 (4): 906-918. | Kurosawa, S. et al. (2003) Expression of the costimulatory molecule B7-H2 (inducible costimulator ligand) by human airway epithelial cells. Am. J. Respir. Cell Mol. Biol. 28: 563-573. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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