CD62P, Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | CD62P, Mouse |
| Clone | REA344 |
| Host Species | Recombinant Human |
| Reactive Species | mouse |
| Isotype | IgG1 |
| Format | PerCP-Vio 700 conjugate |
| Size | 30 µg in 200 µL |
| Concentration | 1:50 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD62P Antibody, anti-mouse, PerCP-Vio® 700, REAfinity™. Clone REA344 recognizes the mouse CD62P antigen, a 140 kDa single-pass type I membrane protein also known as P-selectin or platelet activation dependent granule-external membrane protein (PADGEM). CD62P is expressed by vascular endothelial cells and platelets. The protein is stored preformed in the Weibel-Palade bodies of endothelial cells and in the α-granules of platelets. Upon stimulation of these cells with a variety of agonists such as thrombin or histamine, P-selectin is rapidly translocated to the cell surface, where it mediates leukocyte-platelet and leukocyte-vascular endothelial cell adhesion. The interaction of P-selectin with mature leukocytes is in part responsible for mediating leukocyte rolling on vascular cells, an early event in leukocyte recruitment at sites of inflammation. In addition to its role as a receptor for mature neutrophils and monocytes, P-selectin also functions as a cell adhesion molecule for leukocyte precursor cells in the bone marrow, including both lineage-restricted clonogenic progenitors and hierarchically more primitive progenitor cells. | Additional information: Clone REA344 displays negligible binding to Fc receptors. | |
| Immunogen | n/a |
| Other Names | SELP, GMP-140, GRMP, LECAM3, PADGEM, P-selectin |
| Gene, Accession # | Gene ID: 20344 |
| Catalog # | 130-128-798 |
| Price | $141 |
| Order / More Info | CD62P, Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Sanders, W. E. et al. (1992) Molecular cloning and analysis of in vivo expression of murine P-selectin. Blood 80 (3): 795-800. | Xia, L. et al. (2003) N-terminal residues in murine P-selectin glycoprotein ligand-1 required for binding to murine P-selectin. Blood 101 (2): 552-559. | Weller, A. et al. (1992) Cloning of the mouse endothelial selectins. Expression of both E- and P-selectin is inducible by tumor necrosis factor alpha. J. Biol. Chem. 267 (21): 15176-15183. | Ando, Y. et al. (2016) Platelet supernatant suppresses LPS-induced nitric oxide production from macrophages accompanied by inhibition of NF-κB signaling and increased arginase-1 expression. PLoS One 11: :e0162208. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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