THEMIS, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | THEMIS, Human |
| Clone | REA463 |
| Host Species | Recombinant Human |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | Vio B515 conjugate |
| Size | 100 tests in 200 µL |
| Concentration | 1:50 |
| Applications | Intracellular flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | THEMIS Antibody, anti-human, Vio® B515, REAfinity™. Clone REA463 recognizes the human thymocyte-expressed molecule involved in selection (THEMIS) antigen, a 73 kDa signaling protein, that is also known as thymocyte selection pathway associated (TSEPA), signaling phosphoprotein specific for T cells (SPOT), or GRB2-associated protein (GASP). THEMIS is rapidly tyrosine-phosphorylated upon TCR ligation and is required for the differentiation of immature CD4/CD8 double positive thymocytes into mature CD4 or CD8 single positive thymocytes. It is expressed only in the T cell lineage and is first detected in CD4/CD8 double negative thymocytes, reaching maximum levels at the CD4/CD8 double positive stage. Following thymocyte selection, THEMIS expression is decreased in mature CD4 and CD8 single positive thymocytes and peripheral T cells. Themis-/- mice show impaired positive selection during thymocyte development and severe reduction of mature thymocytes and peripheral T cells. | Additional information: Clone REA463 displays negligible binding to Fc receptors. | | |
| Immunogen | n/a |
| Other Names | C6orf190, C6orf207, GASP, SPOT, TSEPA, THMS1, GRB2-associated protein |
| Gene, Accession # | Gene ID: 387357 |
| Catalog # | 130-129-197 |
| Price | $385 |
| Order / More Info | THEMIS, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Paster, W. et al. (2013) GRB2-mediated recruitment of THEMIS to LAT is essential for thymocyte development. J Immunol 190 (7): 3749-3756. | Paster, W. et al. (2015) A THEMIS: SHP1 complex promotes T-cell survival. EMBO J. 34 (3): 393-409. | Gascoigne, N. R. et al. (2015) THEMIS: a critical TCR signal regulator for ligand discrimination. Curr. Opin. Immunol. 33: 86-92. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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