CD120b (TNF-RII), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | CD120b (TNF-RII), Human |
| Clone | REA520 |
| Host Species | Recombinant Human |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | phycoerythrin (PE) conjugate |
| Size | 100 tests in 200 µL |
| Concentration | 1:50 |
| Applications | Mass cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD120b (TNF-RII) Antibody, anti-human, PE, REAfinity™. Clone REA520 recognizes the extracellular part of the membrane-bound form of the human CD120b antigen, a 75 kDa single-pass type I membrane protein, which is also known as tumor necrosis factor receptor type II (TNF-RII). CD120b is a receptor with high affinity for the cytokine tumor necrosis factor (TNF-α) and for lymphotoxin-alpha (LT-α). It belongs to the TNF receptor superfamily and is largely confined to cells of the immune system. CD120b is strongly expressed on stimulated T and B lymphocytes and on a variety of cells at low levels. Sustained activation of TNF signaling has been implicated in the pathogenesis of a wide spectrum of diseases, including cancer, osteoporosis, sepsis, diabetes, and autoimmune diseases such as multiple sclerosis, rheumatoid arthritis, and inflammatory bowel disease. | Additional information: Clone REA520 displays negligible binding to Fc receptors. | |
| Immunogen | n/a |
| Other Names | TNFRSF1B, TBPII, TNFR-II, TNF-R75, Tnfbr, TNFR1B, TNFR2, TNFR80, p75, p75TNFR |
| Gene, Accession # | Gene ID: 7133 |
| Catalog # | 130-123-778 |
| Price | $315 |
| Order / More Info | CD120b (TNF-RII), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Hostager, B. S. et al. (2002) Role of TNF receptor-associated factor 2 in the activation of IgM secretion by CD40 and CD120b. J Immunol 168 (7): 3318-3322. | Kohno, T. et al. (1990) A second tumor necrosis factor receptor gene product can shed a naturally occurring tumor necrosis factor inhibitor. Proc. Natl. Acad. Sci. U.S.A. 87 (21): 8331-8335. | Hijdra, D. et al. (2012) Differential expression of TNFR1 (CD120a) and TNFR2 (CD120b) on subpopulations of human monocytes. J. Inflamm. 9 (1): 38. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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