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Antigenic Specificity | CD49d, Rat |
Clone | MRα4-1 |
Host Species | Rat |
Reactive Species | rat |
Isotype | IgG2aκ |
Format | phycoerythrin (PE) conjugate |
Size | 30 µg in 200 µL |
Concentration | 1:50 |
Applications | Flow cytometry |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | CD49d Antibody, anti-rat, PE. Clone MRα4-1 recognizes the mouse CD49d antigen, a 150 kDa integrin family member, also known as integrin α4 chain or VLA-4α chain. Integrins are cell-surface receptors, expressed as heterodimers essential in various processes mediating intercellular or cell-matrix interaction. CD49d associates non-covalently with the integrin β or β1 (CD29) forming the complex VLA-4, which is expressed on peripheral lymphocytes, thymocytes, eosinophils, basophils, mast cells, dendritic cells, and monocytes. VLA-4 plays a critical role in adhesion and migration of cells into tissues by binding to its ligand VCAM-1 (CD106). In T cells, on ligation of MAdCAM-1, α4β7 integrin also provides costimulation of T cell receptor/CD3-mediated signaling. |
Immunogen | n/a |
Other Names | ITGA4, α4 integrin chain, VLA-4α chain |
Gene, Accession # | Gene ID: 311144 |
Catalog # | 130-111-483 |
Price | $66 |
Order / More Info | CD49d, Rat Antibody from MILTENYI BIOTEC B.V. & Co. KG |
Product Specific References | Berlin, C. et al. (1993) Alpha 4 beta 7 integrin mediates lymphocyte binding to the mucosal vascular addressin MAdCAM-1. Cell 74 (1): 185-195. | Fogler, W. E. et al. (1996) NK cell infiltration into lung, liver, and subcutaneous B16 melanoma is mediated by VCAM-1/VLA-4 interaction. J Immunol 156 (12): 4707-4714. | Tsuzuki, Y. et al. (1996) alpha 4 integrin plays a critical role in early stages of T lymphocyte migration in Peyer's patches of rats. Int. Immunol. 8 (3): 287-295. |