CD11a, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | CD11a, Human |
| Clone | REA378 |
| Host Species | Recombinant Human |
| Reactive Species | human, nonhuman primate, other |
| Isotype | IgG1 |
| Format | fluorescein (FITC) conjugate |
| Size | 100 tests in 200 µL |
| Concentration | 1:50 |
| Applications | Flow cytometry, MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunocytochemistry, Immunohistochemistry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD11a Antibody, anti-human, FITC, REAfinity™. Clone REA378 recognizes the human CD11a antigen, a single-pass type I membrane protein also known as integrin α-L (ITGAL). Integrins are heterodimeric adhesion molecules comprised of α- and β-subunits that participate in immune cell interactions as well as in immune cell-extracellular matrix interactions. CD11a combines with CD18 (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. LFA-1 is a receptor for CD54 (ICAM-1), CD102 (ICAM-2), CD50 (ICAM-3), and CD242 (ICAM-4). It is involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T cell-mediated killing, and antibody dependent killing by granulocytes and monocytes. Interactions between LFA-1 and CD54 (ICAM-1) play a critical role in T cell-B cell collaboration. | Additional information: Clone REA378 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | ITGAL, LFA-1, LFA1A, Leukocyte function-associated molecule 1 α chain |
| Gene, Accession # | Gene ID: 3683 |
| Catalog # | 130-124-886 |
| Price | $265 |
| Order / More Info | CD11a, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Lowes, M. A. et al. (2005) Increase in TNF-alpha and inducible nitric oxide synthase-expressing dendritic cells in psoriasis and reduction with efalizumab (anti-CD11a). Proc. Natl. Acad. Sci. U.S.A. 102 (52): 19057-19062. | Larson, R. S. et al. (1989) Primary structure of the leukocyte function-associated molecule-1 alpha subunit: an integrin with an embedded domain defining a protein superfamily. J. Cell Biol. 108 (2): 703-712. | Zhou, Y. et al. (2012) Usefulness of CD11a and CD18 in flow cytometric immunophenotypic analysis for diagnosis of acute promyelocytic leukemia. Am. J. Clin. Pathol. 138 (5): 744-750. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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