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Antigenic Specificity | CD85k (ILT3), Human |
Clone | REA141 |
Host Species | Recombinant Human |
Reactive Species | human |
Isotype | IgG1 |
Format | APC-Vio 770 conjugate |
Size | 30 tests in 60 µL |
Concentration | 1:50 |
Applications | Flow cytometry |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | CD85k (ILT3) Antibody, anti-human, APC-Vio® 770, REAfinity™. Clone REA141 recognizes CD85k, a member of regulatory immune receptor family, also known as leukocyte immunoglobulin-like receptor (LILRs/LIRs), immunoglobulin-like transcripts (ILTs), or CD85 family. CD85k is a type I membrane protein with two extracellular Ig-like domains, intracellular immunoreceptor tyrosine-based inhibitory motifs (ITIM) and is expressed on monocytes, dendritic cells, and macrophages. In addition, suppressor T cells induce the expression of CD85k on antigen presenting cells. | Additional information: Clone REA141 displays negligible binding to Fc receptors. | |
Immunogen | n/a |
Other Names | LILRB4, ILT3, LIR-5 |
Gene, Accession # | Gene ID: 11006 |
Catalog # | 130-130-103 |
Price | $166 |
Order / More Info | CD85k (ILT3), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
Product Specific References | Colonna, M. et al. (1997) A common inhibitory receptor for major histocompatibility complex class I molecules on human lymphoid and myelomonocytic cells. J. Exp. Med. 186: 1809-1818. | Cheng, H. et al. (2011) Crystal structure of leukocyte Ig-like receptor LILRB4 (ILT3/LIR-5/CD85k): A myeloid inhibitory receptor involved in immune tolerance. J. Biol. Chem. 286: 18013-18025. | Sommer, A. and Fabri, M. (2015) Vitamin D regulates cytokine patterns secreted by dendritic cells to promote differentiation of IL-22-producing T cells. PLoS One 10 (6): e0130395. |