CD4 (Domain 1), Rat Antibody from MILTENYI BIOTEC B.V. & Co. KG
Search, find, compare suppliers for anti-CD4 (Domain 1), Rat antibody, protein, ELISA kits.
| Edit | |
|---|---|
| Antigenic Specificity | CD4 (Domain 1), Rat |
| Clone | REA482 |
| Host Species | Recombinant Human |
| Reactive Species | rat |
| Isotype | IgG1 |
| Format | PerCP-Vio 700 conjugate |
| Size | 9 µg in 300 µL |
| Concentration | 1:10 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD4 (Domain 1) Antibody, anti-rat, PerCP-Vio® 700, REAfinity™. Clone REA482 recognizes domain 1 of the rat CD4 antigen, a single-pass type I membrane protein also known as T cell surface antigen T4/Leu-3 or W3/25 antigen. CD4 is a member of the immunoglobulin superfamily and is expressed on the surface of T helper cells, monocytes, macrophages, and dendritic cells. It has four immunoglobulin domains (D1 to D4). D1 and D3 resemble immunoglobulin variable (IgV) domains, and D2 and D4 resemble immunoglobulin constant (IgC) domains. CD4 is a co-receptor that assists the T cell receptor (TCR) in communicating with an antigen-presenting cell (APC). CD4 amplifies the signal generated by the TCR by recruiting the tyrosine kinase Lck, which is essential for activating many molecular components of the signaling cascade of an activated T cell. CD4 also interacts directly with MHC class II molecules on the surface of APCs. | Additional information: Clone REA482 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | W3/25, p55, Leu-3 |
| Gene, Accession # | Gene ID: 24932 |
| Catalog # | 130-107-671 |
| Price | $53 |
| Order / More Info | CD4 (Domain 1), Rat Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Clark, S. J. et al. (1987) Peptide and nucleotide sequences of rat CD4 (W3/25) antigen: evidence for derivation from a structure with four immunoglobulin-related domains. Proc. Natl. Acad. Sci. U.S.A. 84 (6): 1649-1653. | Jin, H. et al. (2013) CD4+CD25+Foxp3+ T cells contribute to the antiasthmatic effects of Astragalus membranaceus extract in a rat model of asthma. Int. Immunopharmacol. 15 (1): 42-49. | Almolda, B. et al. (2009) CD4 microglial expression correlates with spontaneous clinical improvement in the acute Lewis rat EAE model. J. Neuroimmunol. 209 (1-2): 65-80. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
Profile of MILTENYI BIOTEC B.V. & Co. KG
Return to Antibodies