DR3, Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG
Search, find, compare suppliers for anti-DR3, Mouse antibody, protein, ELISA kits.
| Edit | |
|---|---|
| Antigenic Specificity | DR3, Mouse |
| Clone | REA475 |
| Host Species | Recombinant Human |
| Reactive Species | mouse |
| Isotype | IgG1 |
| Format | biotin conjugate |
| Size | 30 µg in 1 mL |
| Concentration | 1:10 |
| Applications | Flow cytometry, Intracellular flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | DR3 Antibody, anti-mouse, Biotin, REAfinity™. Clone REA475 recognizes the mouse DR3 antigen, a member of the TNF-receptor superfamily which is also known as tumor necrosis factor receptor superfamily member 25 (TNFRSF25). DR3 is the receptor for TNFSF12 (APO3L, TWEAK) and interacts directly with the adapter TRADD. It is expressed primarily by CD4+ and CD8+ T and NKT cells. DR3 is also highly expressed by FoxP3 positive regulatory T lymphocytes. It mediates activation of NFκB and induces apoptosis. DR3 is activated by TNFSF15, which is rapidly upregulated in antigen presenting cells and some endothelial cells following toll-like receptor or Fc receptor activation. | Additional information: Clone REA475 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | TNFRSF25, Apo-3, DDR3, LARD, TR3, TRAMP, Tnfrsf12, WSL-1, DR3, WSL-1-like |
| Gene, Accession # | Gene ID: 85030 |
| Catalog # | 130-107-125 |
| Price | $59 |
| Order / More Info | DR3, Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Schreiber, T. H. et al. (2010) Therapeutic Treg expansion in mice by TNFRSF25 prevents allergic lung inflammation. J. Clin. Invest. 120 (10): 3629-3640. | Kitson, J. et al. (1996) A death-domain-containing receptor that mediates apoptosis. Nature 384 (6607): 372-375. | Schreiber, T. H. et al. (2013) Immunobiology of TNFSF15 and TNFRSF25. Immunol. Res. 57 (1-3): 3-11. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
Profile of MILTENYI BIOTEC B.V. & Co. KG
Return to Antibodies