CD32, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | CD32, Human |
| Clone | REA997 |
| Host Species | Recombinant Human |
| Reactive Species | human, nonhuman primate, other |
| Isotype | IgG1 |
| Format | purified |
| Size | 100 µg in 100 µL |
| Concentration | n/a |
| Applications | Flow cytometry, MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD32 Antibody, anti-human, pure, REAfinity™. Clone REA997 recognizes the human CD32 antigen, also known as FcγRII. CD32 is a 40 kDa low affinity receptor for the Fc fragment of aggregated IgG. Due to alternative splicing three different isoforms of CD32 are expressed on hematopoietic cells: FcRIIA, FcRIIB, and FcRIIC. The cytoplasmic domains of FcRIIA and FcRIIC contain an activatory ITAM motif whereas FcRIIB is an inhibitory receptor containing an ITIM motif. Different isoforms of CD32 are expressed on B cells, monocytes, dendritic cells, granulocytes, and platelets. Clone REA997 recognizes all isoforms of CD32 without blocking the binding of immune complexes. | Additional information: Clone REA997 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | FCGR2A, FCGR2B, FCGR2C, FcγRII |
| Gene, Accession # | Gene ID: 2212 |
| Catalog # | 130-124-320 |
| Price | $200 |
| Order / More Info | CD32, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Stuart, S. G. et al. (1989) Human IgG Fc receptor (hFcRII; CD32) exists as multiple isoforms in macrophages, lymphocytes and IgG-transporting placental epithelium. EMBO J. 8 (12): 3657-3666. | Van Den Herik-Oudijk, I. E. et al. (1994) Functional analysis of human Fc gamma RII (CD32) isoforms expressed in B lymphocytes. J Immunol 152 (2): 574-585. | Bave, U. et al. (2003) FcγRIIa is expressed on natural IFN-α-producing cells (plasmacytoid dendritic cells) and is required for the IFN-α production induced by apoptotic cells combined with lupus IgG. J Immunol 171: 3296-3302. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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