CD95 (FAS), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | CD95 (FAS), Human |
| Clone | DX2 |
| Host Species | Mouse |
| Reactive Species | human, nonhuman primate |
| Isotype | IgG1κ |
| Format | purified |
| Size | 500 µg in 0.5 mL |
| Concentration | n/a |
| Applications | Mass cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD95 (FAS) Antibody, anti-human, pure-functional grade. CD95, also known as FAS or Apo-1, is a member of the tumor necrosis factor receptor superfamily (TNFR) and is found on the surface of many normal and neoplastically transformed cells. Its ligand, CD95L (FASL/Apo-1L), is able to induce apoptosis in CD95-expressing cells upon binding. CD95 and CD95L are up-regulated on lymphocytes upon activation and are known to play a key role in the regulation of an inflammatory response: Juxtocrine ``fratricide'' of neighbouring lymphocytes via mutual CD95 and CD95L expression helps to terminate immune responses, while apoptosis of pro-inflammatory cells via CD95 helps maintain immune privilege in sites such as the eye, where CD95L is found to be expressed in the retina and cornea. Cross-linking of CD95 receptors by DX2 monoclonal antibody has been described to induce apoptosis in certain target cells. |
| Immunogen | n/a |
| Other Names | FAS, ALPS1A, APO-1, Apt1, FAS1, FASTM, Tnfrsf6 |
| Gene, Accession # | Gene ID: 355 |
| Catalog # | 130-106-328 |
| Price | $370 |
| Order / More Info | CD95 (FAS), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Pitcher, C. J. et al. (2002) Development and homeostasis of T cell memory in rhesus macaque. J Immunol 168: 29-43. | Griffith, T. et al. (1995) Fas ligand-induced apoptosis as a mechanism of immune privilege. Science 270: 1189-1192. | Itoh, N. et al. (1991) The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis. Cell 66: 233-243. | Komada, Y. et al. (1999) Epitopes and functional responses defined by a panel of anti-Fas (CD95) monoclonal antibodies. Hybridoma 18: 391-398. | Lynch, D. et al. (1995) Fas and FasL in the homeostatic regulation of immune responses. Immunol. Today 16: 569-574. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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