CD159a (NKG2A), Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | CD159a (NKG2A), Mouse |
| Clone | REA1161 |
| Host Species | Recombinant Human |
| Reactive Species | mouse |
| Isotype | IgG1 |
| Format | allophycocyanin (APC) conjugate |
| Size | 30 µg in 200 µL |
| Concentration | 1:50 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD159a (NKG2A) Antibody, anti-mouse, APC, REAfinity™. Clone REA1161 recognizes the CD159a (NKG2A) antigen, an inhibitory natural killer (NK) cell receptor. CD159a forms heterodimer with CD94 and contains a C-type lectin ectodomain. Inhibitory signal is transmitted by the heterodimer via immunoreceptor tyrosine-based inhibitory motifs (ITIMs) and upon ligand engagement, ITIMs are phosphorylated and transmit signal through docking of various tyrosine phosphatases. CD159a/CD94 binds non-classical MHC class I protein, HLA-E. Expression of CD159a is found mainly on NK cells, NKT cells, and on subsets of CD8+ cells. | Additional information: Clone REA1161 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | KLRC1, NKG2A |
| Gene, Accession # | Gene ID: 16641 |
| Catalog # | 130-120-378 |
| Price | $93 |
| Order / More Info | CD159a (NKG2A), Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Vance, R. E. et al. (1998) Mouse CD94/NKG2A is a natural killer cell receptor for the nonclassical major histocompatibility complex (MHC) class I molecule Qa-1(b). J. Exp. Med. 188 (10): 1841-1848. | Vance, R. E. et al. (2002) Implications of CD94 deficiency and monoallelic NKG2A expression for natural killer cell development and repertoire formation. Proc. Natl. Acad. Sci. U.S.A. 99 (2): 868-873. | Rapaport, A. S. et al. (2015) The inhibitory receptor NKG2A sustains virus-specific CD8+ T cells in response to a lethal poxvirus infection. Immunity 43 (6): 1112-1124. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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