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Antigenic Specificity | CD184 (CXCR4), Human |
Clone | 12G5 |
Host Species | Mouse |
Reactive Species | human, nonhuman primate |
Isotype | IgG2aκ |
Format | allophycocyanin (APC) conjugate |
Size | 30 tests in 60 µL |
Concentration | 1:50 |
Applications | Flow cytometry |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | CD184 (CXCR4) Antibody, anti-human, APC. The monoclonal antibody 12G5 recognizes human CD184, also known as CXCR4 or fusin, a 45 kDa seven transmembrane G-protein-linked chemokine receptor for SDF-1. CXCR4 is ubiquitously expressed on blood and tissue cells. It mediates chemotaxis in mature and progenitor blood cells and is important for B lympho- and myelopoiesis and cardiogenesis. It is reported to block CD4-independent HIV-2 infection and CD4-dependent infection by some T cell tropic isolates of HIV-1. |
Immunogen | n/a |
Other Names | CXCR4, LAP-3, LCR1, LESTR, NPY3R, WHIM, WHIMS, Fusin |
Gene, Accession # | Gene ID: 7852 |
Catalog # | 130-124-017 |
Price | $140 |
Order / More Info | CD184 (CXCR4), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
Product Specific References | Ichiyama, K. et al. (2003) A duodenally absorbable CXC chemokine receptor 4 antagonist, KRH-1636, exhibits a potent and selective anti-HIV-1 activity. Proc. Natl. Acad. Sci. U.S.A. 100: 4185-4190. | Berger, E. A. et al. (1999) Chemokine receptors as HIV-1 coreceptors: roles in viral entry, tropism, and disease. Annu. Rev. Immunol. 17: 657-700. | Loetscher, P. et al. (2000) Chemokines and their receptors in lymphocyte traffic and HIV infection. Adv. Immunol. 74: 127-180. | McKnight, A. et al. (1997) Inhibition of human immunodeficiency virus fusion by a monoclonal antibody to a coreceptor (CXCR4) is both cell type and virus strain dependent. J. Virol. 71 (2): 1692-1696. |