Histone H3 (tri methyl K4), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | Histone H3 (tri methyl K4), Human |
| Clone | REAL1335 |
| Host Species | Recombinant Human |
| Reactive Species | human |
| Isotype | n/a |
| Format | phycoerythrin (PE) conjugate |
| Size | 200 µL |
| Concentration | n/a |
| Applications | MICS (MACSima Imaging Cyclic Staining), Immunohistochemistry, Immunofluorescence |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Histone H3 (tri methyl K4) Antibody, anti-human, PE, REAdye_lease™. Clone REAL1335 is an antibody fragment derived from the full Histone H3 (tri methyl K4) antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAdye_lease Complex to bind markers with high avidity. | Clone REAL1335 recognizes the human Histone H3 (tri methyl K4), a core component of the nucleosome. Histones are highly conserved proteins that serve as the structural scaffold for the organization of nuclear DNA into chromatin. Histone H3 is one of the five histones that are mainly involved in building the structure of chromatin in eukaryotic cells. Histone modifications induce changes of chromatin structure and thereby affect the accessibility of transcription factors, nuclear proteins and enzymes to genomic DNA, resulting in gene activation or repression. It is known that histone modification plays critical roles in DNA repair, DNA replication, transcription regulation, alternative splicing, chromosome condensation and some diseases including autoimmune diseases and cancers. | For removal of REAdye_lease fluorochromes for optional relabeling with different fluorochrome-conjugated REAdye_lease antibodies use the REAlease Support Kit (130-120-675). | |
| Immunogen | n/a |
| Other Names | PRDM9, Protein-lysine N-methyltransferase PRDM9, Histone-lysine N-methyltransferase PRDM9, PR domain zinc finger protein 9, PR domain-containing protein 9 |
| Gene, Accession # | n/a |
| Catalog # | 130-130-519 |
| Price | $460 |
| Order / More Info | Histone H3 (tri methyl K4), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Eram, M. S. et al. (2014) Trimethylation of histone H3 lysine 36 by human methyltransferase PRDM9 protein. J. Biol. Chem. 289 (17): 12177-12188. | Beyer, S. et al. (2017) Histone H3 Acetyl K9 and Histone H3 Tri Methyl K4 as Prognostic Markers for Patients with Cervical Cancer. Int J Mol Sci 18 (3): 477. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
Profile of MILTENYI BIOTEC B.V. & Co. KG