Ly-49C/I, Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | Ly-49C/I, Mouse |
| Clone | REA253 |
| Host Species | Recombinant Human |
| Reactive Species | mouse |
| Isotype | IgG1 |
| Format | biotin conjugate |
| Size | 9 µg in 300 µL |
| Concentration | 1:10 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Ly-49C/I Antibody, anti-mouse, Biotin, REAfinity™. Clone REA253 recognizes the mouse lymphocyte antigen 49c (Ly-49C), a type II transmembrane protein which is also known as killer cell lectin-like receptor 3 (Klra3). The REA253 antibody reacts with Ly-49C of BALB, B6, NZB, C57BL, and Ly-49I of B6 mice strains. Ly-49 family members are both activating and inhibitory receptors and are mainly receptors for MHC class I molecules. Ly-49C is a cell surface molecule expressed on a subpopulation of murine natural killer cells and NK1.1 T cells that are involved in the specific rejection of H-2d or H-2f (hemopoietic histocompatibility determinant 2) bone marrow cell grafts. It transduces a negative signal to NK cells upon recognition of class I antigens. The particular allele of Ly-49C, i.e., C57BL versus BALB, determines to a large extent which class I antigen (H-2Kb for B6, Kb and H-2d for BALB/c or BALB.B) sends negative signals to Ly-49C+ NK cells. Clone REA253 blocks the binding of Ly-49C to MHC class I antigens of the b, d, k, and s haplotypes. The epitope recognized by REA253 may be masked on NK cells due to interactions with MHC class I molecules. | Additional information: Clone REA253 displays negligible binding to Fc receptors. | |
| Immunogen | n/a |
| Other Names | Klra3, Klra9 |
| Gene, Accession # | Gene ID: 16634, 16640 |
| Catalog # | 130-102-132 |
| Price | $36 |
| Order / More Info | Ly-49C/I, Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Yu, Y. Y. et al. (1996) The role of Ly49A and 5E6(Ly49C) molecules in hybrid resistance mediated by murine natural killer cells against normal T cell blasts. Immunity 4 (1): 67-76. | Brennan, J. et al. (1996) Heterogeneity among Ly-49C natural killer (NK) cells: characterization of highly related receptors with differing functions and expression patterns. J. Exp. Med. 184 (6): 2085-2090. | Stoneman, E. R. et al. (1995) Cloning and characterization of 5E6(Ly-49C), a receptor molecule expressed on a subset of murine natural killer cells. J. Exp. Med. 182 (2): 305-313. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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