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Antigenic Specificity | CD170 (Siglec-5), Human |
Clone | REA1077 |
Host Species | Recombinant Human |
Reactive Species | human, nonhuman primate |
Isotype | IgG1 |
Format | biotin conjugate |
Size | 30 tests in 60 µL |
Concentration | 1:50 |
Applications | Flow cytometry |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | CD170 (Siglec-5) Antibody, anti-human, Biotin, REAfinity™. Clone REA1077 recognizes the CD170 antigen, a single-pass transmembrane protein member of the immunoglobulin superfamily, also known as sialic acid-binding Ig-like lectin 5 (Siglec-5). CD170 is expressed on neutrophils, monocytes, dendritic cells, and subsets of tissue macrophages. It contains two tyrosine-based motifs in its cytoplasmic tail implicating signaling functions and forms a 140 kDa dimer on the cell surface. Tyrosine phosphorylation of CD170 leads to recruitment of the tyrosine phosphatases SHP-1 and SHP-2, which in turn efficiently inhibits FcεRI-mediated calcium fluxing and serotonin release. CD170 binds α 2-3- and α 2-6-linked sialic acid as well as glycophorin A, and is involved in cell adhesion. | Additional information: Clone REA1077 displays negligible binding to Fc receptors. |
Immunogen | n/a |
Other Names | CD33L2, OB-BP2, OBBP2, Siglec-5 |
Gene, Accession # | Gene ID: 8778 |
Catalog # | 130-119-201 |
Price | $93 |
Order / More Info | CD170 (Siglec-5), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
Product Specific References | Cornish, A. L. et al. (1998) Characterization of Siglec-5, a novel glycoprotein expressed on myeloid cells related to CD33. Blood 92 (6): 2123-2132. | Erickson-Miller, C. L. et al. (2003) Characterization of Siglec-5 (CD170) expression and functional activity of anti-Siglec-5 antibodies on human phagocytes. Exp. Hematol. 31 (5): 382-388. | Avril, T. et al. (2005) Siglec-5 (CD170) can mediate inhibitory signaling in the absence of immunoreceptor tyrosine-based inhibitory motif phosphorylation. J. Biol. Chem. 280: 19843-19851. |