CD8b.2, Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | CD8b.2, Mouse |
| Clone | REA865 |
| Host Species | Recombinant Human |
| Reactive Species | mouse |
| Isotype | IgG1 |
| Format | biotin conjugate |
| Size | 30 µg in 200 µL |
| Concentration | 1:50 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD8b.2 Antibody, anti-mouse, Biotin, REAfinity™. Clone REA865 recognizes the β chain of the mouse CD8 antigen, a single-pass type I membrane protein also known as lymphocyte antigen 3 (Ly-3.2 or Lyt-3.2). The CD8 molecule is composed of two distinct polypeptide chains that pair on the cell surface either as a CD8 αα homodimer or as a CD8 αβ heterodimer. These forms of the CD8 molecule are differentially expressed on functionally distinct CD8+ lymphocyte subsets. The CD8 αβ heterodimer is expressed on cytotoxic T cells and thymocytes. CD8b functions as a co-receptor for the T cell receptor (TCR). | Additional information: Clone REA865 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | Lyt-3.2, Ly-3.2 |
| Gene, Accession # | Gene ID: 12526 |
| Catalog # | 130-114-383 |
| Price | $64 |
| Order / More Info | CD8b.2, Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Chang, H. C. et al. (2005) Structural and mutational analyses of a CD8alphabeta heterodimer and comparison with the CD8alphaalpha homodimer. Immunity 23 (6): 661-671. | Renard, V. et al. (1996) CD8 beta increases CD8 coreceptor function and participation in TCR-ligand binding. J. Exp. Med. 184 (6): 2439-2444. | Gao, G. F. et al. (2000) Molecular interactions of coreceptor CD8 and MHC class I: the molecular basis for functional coordination with the T-cell receptor. Immunol. Today 21 (12): 630-636. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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