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Antigenic Specificity | CD8b.2, Mouse |
Clone | REA865 |
Host Species | Recombinant Human |
Reactive Species | mouse |
Isotype | IgG1 |
Format | phycoerythrin (PE) conjugate |
Size | 30 µg in 200 µL |
Concentration | 1:50 |
Applications | Flow cytometry |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | CD8b.2 Antibody, anti-mouse, PE, REAfinity™. Clone REA865 recognizes the β chain of the mouse CD8 antigen, a single-pass type I membrane protein also known as lymphocyte antigen 3 (Ly-3.2 or Lyt-3.2). The CD8 molecule is composed of two distinct polypeptide chains that pair on the cell surface either as a CD8 αα homodimer or as a CD8 αβ heterodimer. These forms of the CD8 molecule are differentially expressed on functionally distinct CD8+ lymphocyte subsets. The CD8 αβ heterodimer is expressed on cytotoxic T cells and thymocytes. CD8b functions as a co-receptor for the T cell receptor (TCR). | Additional information: Clone REA865 displays negligible binding to Fc receptors. |
Immunogen | n/a |
Other Names | Lyt-3.2, Ly-3.2 |
Gene, Accession # | Gene ID: 12526 |
Catalog # | 130-114-385 |
Price | $72 |
Order / More Info | CD8b.2, Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG |
Product Specific References | Chang, H. C. et al. (2005) Structural and mutational analyses of a CD8alphabeta heterodimer and comparison with the CD8alphaalpha homodimer. Immunity 23 (6): 661-671. | Renard, V. et al. (1996) CD8 beta increases CD8 coreceptor function and participation in TCR-ligand binding. J. Exp. Med. 184 (6): 2439-2444. | Gao, G. F. et al. (2000) Molecular interactions of coreceptor CD8 and MHC class I: the molecular basis for functional coordination with the T-cell receptor. Immunol. Today 21 (12): 630-636. |