CD267 (TACI), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | CD267 (TACI), Human |
| Clone | 1A1 |
| Host Species | Rat |
| Reactive Species | human |
| Isotype | IgG2aκ |
| Format | phycoerythrin (PE) conjugate |
| Size | 30 tests in 300 µL |
| Concentration | 1:11 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD267 (TACI) Antibody, anti-human, PE. Clone 1A1 recognizes human CD267, a 32 kDa type III transmembrane protein belonging to the TNF receptor superfamily. CD267 as receptor binds to BAFF and APRIL and plays an important role in the stimulation of B and T cell-function and in the regulation of humoral immunity. CD267 expression is found in CD27+ memory B cells, tonsillar and bone marrow plasma cells, in a subpopulation of activated CD27-, non-GC cells, and in a small subset of naive blood and tonsil B cells. CD267 is also expressed on many lymphomas such as multiple myeloma and Hodgkin and non-Hodgkin lymphomas. Mutations in CD267 are often associated with common variable immunodeficiency in humans. Signaling via CD267 leads to activation of the transcription factors NFAT, AP1, and NF-κB. |
| Immunogen | n/a |
| Other Names | TNFRSF13B, CVID, CVID2, IGAD2, RYZN, TACI, TNFRSF14B |
| Gene, Accession # | Gene ID: 23495 |
| Catalog # | 130-100-663 |
| Price | $110 |
| Order / More Info | CD267 (TACI), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Salzer, U. et al. (2005) Mutations in TNFRSF13B encoding TACI are associated with common variable immunodeficiency in humans. Nat. Genet. 37 (8): 820-828. | Mackay, F. et al. (2008) TACI, an enigmatic BAFF/APRIL receptor, with new unappreciated biochemical and biological properties. Cytokine Growth Factor Rev. 19 (3-4): 263-276. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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