C3a Receptor, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | C3a Receptor, Human |
| Clone | hC3aRZ8 |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | IgG2b |
| Format | allophycocyanin (APC) conjugate |
| Size | 30 tests in 300 µL |
| Concentration | 1:11 |
| Applications | Flow cytometry, MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | C3a Receptor Antibody, anti-human, APC. Clone hC3aRZ8 recognizes the human C3a anaphylatoxin chemotactic receptor (C3aR) antigen, a 54 kDa seven transmembrane GTP-binding-protein-coupled receptor which belongs to the rhodopsin supergene family. C3aR is expressed by various cells, including cells of hematopoietic origin such as neutrophils and monocytes, but also non-hematopoietic cells such as renal proximal tubular epithelial cells or neural cells. C3aR functions as a cell surface receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a, a C-terminal 77 amino acid cleavage product of the alpha chain of C3. All cellular responses to C3a are specifically mediated by interactions with the membrane bound C3aR. After C3a binding, the C3aR signaling results in chemotaxis, granule enzyme release, and superoxide anion production. C3aR binding on T cells promotes CD4+ and CD8+ T cell activation, proliferation, differentiation, and survival, independently of TCR signals. | |
| Immunogen | n/a |
| Other Names | C3AR1, AZ3B, C3AR, HNFAG09 |
| Gene, Accession # | Gene ID: 719 |
| Catalog # | 130-108-110 |
| Price | $142 |
| Order / More Info | C3a Receptor, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Crass, T. et al. (1996) Expression cloning of the human C3a anaphylatoxin receptor (C3aR) from differentiated U-937 cells. Eur. J. Immunol. 26 (8): 1944-1950. | Ames, R. S. et al. (1996) Molecular cloning and characterization of the human anaphylatoxin C3a receptor. J. Biol. Chem. 271 (34): 20231-20234. | Gao, J. et al. (2003) Sulfation of tyrosine 174 in the human C3a receptor is essential for binding of C3a anaphylatoxin. J. Biol. Chem. 278 (39): 37902-37908. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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