CD156c (ADAM10), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | CD156c (ADAM10), Human |
| Clone | REA309 |
| Host Species | Recombinant Human |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | allophycocyanin (APC) conjugate |
| Size | 100 tests in 1 mL |
| Concentration | 1:11 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD156c (ADAM10) Antibody, anti-human, APC, REAfinity™. Clone REA309 recognizes the human CD156c antigen, a single-pass type I membrane protein which is also known as disintegrin or metalloproteinase domain-containing protein 10 (ADAM10). CD156c belongs to the family of disintegrin and metalloproteinases (ADAMs) and is expressed ubiquitously on hematopoietic and non-hematopoietic cells. ADAMs have emerged as the major proteinase family that mediates proteolytic ectodomain release, a process known as shedding. This shedding process has been recognised as a key mechanism for regulating the function of a diversity of cell surface proteins. Dysregulation of ectodomain shedding is associated with autoimmune and cardiovascular diseases, neurodegeneration, infection, inflammation, and cancer. CD156c has been studied in the context of ectodomain shedding and has been demonstrated as key molecule in most of the shedding events in cancer and neurodegenerative disorders. | Additional information: Clone REA309 displays negligible binding to Fc receptors. | |
| Immunogen | n/a |
| Other Names | ADAM10, AD10, AD18, HsT18717, MADM, RAK, kuz |
| Gene, Accession # | Gene ID: 102 |
| Catalog # | 130-104-408 |
| Price | $325 |
| Order / More Info | CD156c (ADAM10), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Weber, C. et al. (2013) Regulation of adult hematopoiesis by the a disintegrin and metalloproteinase 10 (ADAM10). Biochem. Biophys. Res. Commun. 442 (3-4): 234-241. | Moss, M. L. and Bartsch, J. W. (2004) Therapeutic benefits from targeting of ADAM family members. Biochem. J. 43 (23): 7227-7235. | Rosendahl, M. S. et al. (1997) Identification and characterization of a pro-tumor necrosis factor-alpha-processing enzyme from the ADAM family of zinc metalloproteases. J. Biol. Chem. 272 (39): 24588-24593. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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