CD49f, Human/Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | CD49f, Human/Mouse |
| Clone | REA518 |
| Host Species | Recombinant Human |
| Reactive Species | human, mouse, nonhuman primate, other |
| Isotype | IgG1 |
| Format | biotin conjugate |
| Size | 100 tests in 200 µL |
| Concentration | 1:50 |
| Applications | Flow cytometry, MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD49f Antibody, anti-human/mouse, Biotin, REAfinity™. Clone REA518 recognizes the human and mouse CD49f antigen, a 120 kDa single-pass type I membrane protein, which is also known as integrin alpha-6 (ITGA6). Integrins are integral cell-surface proteins composed of an α chain and a β chain and are involved in cell adhesion as well as cell-surface mediated signaling. CD49f associates with integrin β1 chain (CD29) to form VLA-6 and with integrin β4 chain (CD104) to form the α6 β4 complex, which plays a critical structural role in the hemidesmosome and constitutes a receptor for laminin in epithelial cells. CD49f is furthermore expressed on T cells, monocytes, platelets, endothelial cells, trophoblasts of placenta, and spermatogonial stem cells. | Additional information: Clone REA518 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | ITGA6, CD49fB, VLA-6, α6 integrin, VLA-6α |
| Gene, Accession # | Gene ID: 3655, 16403 |
| Catalog # | 130-123-243 |
| Price | $270 |
| Order / More Info | CD49f, Human/Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Hynes, R. O. (2002) Integrins: bidirectional, allosteric signaling machines. Cell 110 (6): 673-687. | Aumailley, M. et al. (1990) Antibody to integrin α 6 subunit specifically inhibits cell-binding to laminin fragment 8. Exp. Cell Res. 188 (1): 55-60. | Hemler, M. E. et al. (1988) Multiple very late antigen (VLA) heterodimers on platelets. Evidence for distinct VLA-2, VLA-5 (fibronectin receptor), and VLA-6 structures. J. Biol. Chem. 263: 7660-7665. | Carter, W. G. et al. (1990) Distinct functions for integrins α 3 β 1 in focal adhesions and α 6 β 4/bullous pemphigoid antigen in a new stable anchoring contact (SAC) of keratinocytes: relation to hemidesmosomes. J. Cell Biol. 111: 3141-3154. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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