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Antigenic Specificity | CD49e, Human |
Clone | REA686 |
Host Species | Recombinant Human |
Reactive Species | human, nonhuman primate |
Isotype | IgG1 |
Format | Vio Bright FITC conjugate |
Size | 100 tests in 200 µL |
Concentration | 1:50 |
Applications | Flow cytometry, MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | CD49e Antibody, anti-human, Vio® Bright FITC, REAfinity™. Clone REA686 recognizes the human CD49e antigen, also known as integrin α5 chain. Integrins are cell-surface receptors, expressed as heterodimers essential in various processes mediating intercellular or cellmatrix interaction. Integrin α5 is composed of a heavy and a light chain linked by a disulfide bond. CD49e associates non-covalently with the integrin β1 (CD29) forming the very late activation antigen-5 (VLA5) complex which is expressed on many cell types including peripheral lymphocytes, monocytes, fibroblasts, and endothelial cells and is a receptor for fibronectin and fibrinogen but functions also as a receptor for laminin and several other extracellular matrix proteins. | Additional information: Clone REA686 displays negligible binding to Fc receptors. |
Immunogen | n/a |
Other Names | VLA-5α, α5 integrin, VLA-5, Integrin alpha-5 |
Gene, Accession # | Gene ID: 3678 |
Catalog # | 130-110-534 |
Price | $395 |
Order / More Info | CD49e, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
Product Specific References | Riedl, E. et al. (2000) Functional involvement of E-cadherin in TGF-beta 1-induced cell cluster formation of in vitro developing human Langerhans-type dendritic cells. J Immunol 165 (3): 1381-1386. | Takada, Y. et al. (1987) The very late antigen family of heterodimers is part of a superfamily of molecules involved in adhesion and embryogenesis. Proc. Natl. Acad. Sci. U.S.A. 84: 3239-3243. | Takagi, J. et al. (2003) Structure of integrin alpha5beta1 in complex with fibronectin. EMBO J. 22: 4607-4615. | Lomakina, E. B and Waugh, R. E. (2009) Adhesion between human neutrophils and immobilized endothelial ligand vascular cell adhesion molecule 1: divalent ion effects. Biophys. J. 96 (1): 276-284. |