Bcl-6, Human/Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | Bcl-6, Human/Mouse |
| Clone | REA373 |
| Host Species | Recombinant Human |
| Reactive Species | human, mouse |
| Isotype | IgG1 |
| Format | allophycocyanin (APC) conjugate |
| Size | 100 tests in 200 µL |
| Concentration | 1:50 |
| Applications | Intracellular flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Bcl-6 Antibody, anti-human/mouse, APC, REAfinity™. Clone REA373 recognizes the human and mouse Bcl-6 antigen, a member of the BTB-zinc finger family of proteins. Bcl-6 is a transcriptional repressor, expressed in germinal center T and B cells and in primary immature dendritic cells. It plays critical functions in various cell types within the adaptive and innate compartments of the immune system. Bcl-6 is highly up-regulated in B cells after T cell-dependent antigenic challenge, and is required for formation of germinal centers within which B cells undergo immunoglobulin affinity maturation. It also plays an important role in macrophages, where it mediates a dampening effect on inflammatory signaling through repression of chemokine expression and NF-κB target genes. | Additional information: Clone REA373 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | BCL6, BCL5, BCL6A, LAZ3, ZBTB27, ZNF51 |
| Gene, Accession # | Gene ID: 604, 12053 |
| Catalog # | 130-121-997 |
| Price | $325 |
| Order / More Info | Bcl-6, Human/Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Shaffer, A. L. et al. (1997) In vivo occupancy of the kappa light chain enhancers in primary pro- and pre-B cells: a model for kappa locus activation. Immunity 6: 131-143. | Huang, C. et al. (2000) Lineage-specific functions of Bcl-6 in immunity and inflammation are mediated by distinct biochemical mechanisms. Nat Immunol 14 (4): 380-388. | Kerckaert, J. P. et al. (1993) LAZ3, a novel zinc-finger encoding gene, is disrupted by recurring chromosome 3q27 translocations in human lymphomas. Nat. Genet. 5 (1): 66-70. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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