CD357 (GITR), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | CD357 (GITR), Human |
| Clone | REA1007 |
| Host Species | Recombinant Human |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | biotin conjugate |
| Size | 100 tests in 200 µL |
| Concentration | 1:50 |
| Applications | Flow cytometry, MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD357 (GITR) Antibody, anti-human, Biotin, REAfinity™. Clone REA1007 recognizes the human CD357 antigen, also known as glucocorticoid-induced tumor necrosis factor receptor-related protein (GITR) or TNFRSF18, which is an inducible type I transmembrane protein and a member of the tumor necrosis factor receptor (TNFR) superfamily. CD357 is expressed at low levels on thymocyte subsets, resting T cells, B cells, and macrophages, and at high levels on CD4+CD25+ regulatory T cells (Tregs). Upon activation, expression on CD4+ and CD8+ T cells is upregulated. Triggering of GITR has been described to modulate Treg function and co-stimulate effector T cells. Stimulation of T cells through GITR can abrogate the inhibitory function of Tregs. It is hypothesized that GITR has a role in the maintenance of immunological self tolerance, and mouse models of autoimmune disease suggest that GITR activation may break self-tolerance and induce autoimmunity. | Additional information: Clone REA1007 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | TNFRSF18, AITR, GITR |
| Gene, Accession # | Gene ID: 8784 |
| Catalog # | 130-116-844 |
| Price | $270 |
| Order / More Info | CD357 (GITR), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Nocentini, G. et al. (1997) A new member of the tumor necrosis factor/nerve growth factor receptor family inhibits T cell receptor-induced apoptosis. Proc. Natl. Acad. Sci. U.S.A. 94: 6216-6221. | Gurney, A. L. et al. (1999) Identification of a new member of the tumor necrosis factor family and its receptor, a human ortholog of mouse GITR. Curr. Biol. 9: 215-218. | Nocentini, G. et al. (2007) GITR/GITRL: more than an effector T cell co-stimulatory system. Eur. J. Immunol. 37: 1165-1169. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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