CD126 (IL-6Rα), Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | CD126 (IL-6Rα), Mouse |
| Clone | D7715A7 |
| Host Species | Rat |
| Reactive Species | mouse |
| Isotype | IgG2bκ |
| Format | allophycocyanin (APC) conjugate |
| Size | 30 µg in 1 mL |
| Concentration | 1:10 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD126 (IL-6Rα) Antibody, anti-mouse, APC. Clone D7715A7 recognizes the mouse CD126 antigen, a type I cytokine receptor also known as interleukin 6 receptor subunit alpha (IL-6Rα) or membrane glycoprotein 80 (gp80). CD126 is expressed on activated T and B cells, monocytes, hepatocytes, and plasma cells. It associates with the IL-6 receptor β chain (CD130 or gp130) resulting in the formation of a functional high affinity IL-6 receptor complex. IL-6 plays essential roles in immune response, acute phase reaction, and hematopoiesis. It is an essential factor for B cell differentiation to antibody-forming cells. Deregulated expression of the IL-6 gene is involved in polyclonal plasma cell abnormalities and oncogenesis of plasma cell neoplasias. IL-6 functions as a potent growth factor for multiple myelomas, as well as plasmacytomas. Clone D7715A7 blocks IL-6/IL-6 receptor interactions. | |
| Immunogen | n/a |
| Other Names | IL6RA, IL-6R, IL-6R-alpha, IL-6RA, IL-6R 1 |
| Gene, Accession # | Gene ID: 16194 |
| Catalog # | 130-105-849 |
| Price | $88 |
| Order / More Info | CD126 (IL-6Rα), Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Yadav, M. et al. (2008) Cutting edge: vasoactive intestinal peptide (VIP) induces differentiation of Th17 cells with a distinctive cytokine Profile. J Immunol 180 (5): 2772-2776. | Walker, F. et al. (2008) IL6/sIL6R complex contributes to emergency granulopoietic responses in G-CSF- and GM-CSF-deficient mice. Blood 111 (8): 3978-3985. | Sugita, T. et al. (1990) Functional murine interleukin 6 receptor with the intracisternal A particle gene product at its cytoplasmic domain. Its possible role in plasmacytomagenesis. J. Exp. Med. 171 (6): 2001-2009. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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