QA-1B, Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | QA-1B, Mouse |
| Clone | 6A8.6F10.1A6 |
| Host Species | Mouse |
| Reactive Species | mouse |
| Isotype | IgG1κ |
| Format | biotin conjugate |
| Size | 30 µg in 200 µL |
| Concentration | 1:50 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | QA-1B Antibody, anti-mouse, Biotin. Clone 6A8.6F10.1A6 recognizes murine QA-1B, a 48 kDa non-classical MHC class Ib molecule encoded by the H2-T23 gene on chromosome 17. QA-1 associates with β2-microglobulin and its surface expression is found on activated hematopoietic cells, T cells, dendritic cells (DCs), macrophages, and neurons. Murine QA-1 presents a nine amino acid peptide called QA-1 determinant modifier (Qdm), peptides from proteins associated with infectious or inflammatory response, and a heat shock protein 60 (HSP60)-derived peptide (in the absence of Qdm) to immunoregulatory CD8+ T cells. QA-1B also serves as a ligand for C-type lectin CD94/NKG2 receptors and depending on the NKG2 family member involved, this interaction can result in an inhibitory or an activating signal. |
| Immunogen | n/a |
| Other Names | H2-T23 |
| Gene, Accession # | Gene ID: 15040 |
| Catalog # | 130-132-435 |
| Price | $56 |
| Order / More Info | QA-1B, Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Lu, L. et al. (2007) Regulation of activated CD4+ T cells by NK cells via the Qa-1-NKG2A inhibitory pathway. Immunity 26 (5): 593-604. | Vance, R. E. et al. (1999) Recognition of the class Ib molecule Qa-1b by putative activating receptors CD94/NKG2C and CD94/NKG2E on mouse natural killer cells. J. Exp. Med. 190: 1801-1812. | Lu, L. et al. (2006) The immunoregulatory effects of Qa-1. Immunol. Rev. 212: 51-59. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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