Siglec-10, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | Siglec-10, Human |
| Clone | 5G6 |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | IgG1κ |
| Format | allophycocyanin (APC) conjugate |
| Size | 30 tests in 300 µL |
| Concentration | 1:11 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Siglec-10 Antibody, anti-human, APC. Clone 5G6 recognizes the sialic acid-binding Ig-like lectin 10 (Siglec-10) antigen, a member of the CD33-related group of siglecs. The cytoplasmic tail of Siglec-10 contains four tyrosines, two of which are embedded in ITIM-signaling motifs and are likely to be involved in intracellular signaling. Amongst peripheral blood leucocytes, Siglec-10 was found to be expressed on eosinophils, monocytes, and B cells. Higher levels of Siglec-10 were found on a minor subset of NK-like cells that express the CD16 low-affinity Fc receptor but lack the CD56 antigen. The molecular properties and expression pattern suggest that Siglec-10 may have evolved to function as an inhibitory receptor of the innate immune system. |
| Immunogen | n/a |
| Other Names | PRO940, SLG2, Siglec10, Siglec-like protein 2 (SLG2) |
| Gene, Accession # | Gene ID: 89790 |
| Catalog # | 130-103-731 |
| Price | $142 |
| Order / More Info | Siglec-10, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Bandala-Sanchez, E. et al. (2013) T cell regulation mediated by interaction of soluble CD52 with the inhibitory receptor Siglec-10. Nat Immunol 14 (7): 741-748. | Kitzig, F. et al. (2002) Cloning of two new splice variants of Siglec-10 and mapping of the interaction between Siglec-10 and SHP-1. Biochem. Biophys. Res. Commun. 296 (2): 355-362. | Munday, J. et al. (2001) Identification, characterization, and leucocyte expression of siglec-10, a novel human sialic acid-binding receptor. Biochem. J. 355: 489-497. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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