CD177, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | CD177, Human |
| Clone | REA258 |
| Host Species | Recombinant Human |
| Reactive Species | human, nonhuman primate |
| Isotype | IgG1 |
| Format | PE-Vio 770 conjugate |
| Size | 100 tests in 1 mL |
| Concentration | 1:11 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD177 Antibody, anti-human, PE-Vio® 770, REAfinity™. Clone REA258 recognizes CD177, which is also known as neutrophil specific antigen 1. CD177, a member of the µPAR family, is a 58-64 kDa glycosylphosphatidylinositol-anchored glycoprotein expressed exclusively by subset of neutrophils, neutrophilic metamyelocytes, and myelocytes and is suggested to play a role in neutrophil mediated immune reponse as evident by its up-regulation on neutrophils in a number of inflammatory settings such as bacterial infection. Furthermore, CD177 can directly bind to PECAM-1 allowing neutrophil-endothelial cell interactions and thus contributing to neutrophil transmigration. Overexpression of CD177 is also seen in patients with polycythemia vera, making it a useful diagnostic marker. | Additional information: Clone REA258 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | HNA-2a, NB1, NB1 GP, PRV-1, PRV1 |
| Gene, Accession # | Gene ID: 57126 |
| Catalog # | 130-101-527 |
| Price | $350 |
| Order / More Info | CD177, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Sachs, U. J. H. et al. (2007) The neutrophil-specific antigen CD177 is a counter-receptor for platelet endothelial cell adhesion molecule-1 (CD31). J. Biol. Chem. 282: 23603 -23612. | Monti, M. et al. (2017) Integrin-dependent cell adhesion to neutrophil extracellular traps through engagement of fibronectin in neutrophil-like cells. PLoS One 12 (2): . | Beyrau, M. et al. (2012) Neutrophil heterogeneity in health and disease: a revitalized avenue in inflammation and immunity. Open Bio 2: 120134. | Wu, Z. et al. (2016) Heterogeneity of human neutrophil CD177 expression results from CD177P1 pseudogene conversion. PLoS Genet. 12 (5): . | Tackeray, J. T. et al. (2016) Targeting amino acid metabolism for molecular imaging of inflammation early after myocardial infarction. Theranostics 6 (11): 1768-1779. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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