CD317 (PDCA-1), Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | CD317 (PDCA-1), Mouse |
| Clone | JF05-1C2.4.1 |
| Host Species | Rat |
| Reactive Species | mouse |
| Isotype | IgG2b |
| Format | phycoerythrin (PE) conjugate |
| Size | 30 µg in 1 mL |
| Concentration | 1:10 |
| Applications | Mass cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD317 (PDCA-1) Antibody, anti-mouse, PE. Clone JF05-1C2.4.1 specifically recognizes the mouse CD317 antigen, also known as plasmacytoid dendritic cell antigen-1 (PDCA-1). CD317 is specifically expressed on mouse PDCs, a subset of CD11c+ dendritic cells detected at low frequency in all lymphoid tissues, peripheral blood, and some non-lymphoid tissues. | In mouse spleen, bone marrow, and lymph nodes, CD317 is exclusively expressed on cells which are CD11clow, Ly-6Chigh, CD45R (B220)+, MHC class IIlow, CD8alow/-, CD80low/-, CD86-, CD40-, CD11b-, CD90-, CD49b (DX5)-, CD3-, CD19-, i.e. on cells with the phenotype of mouse PDCs. Multi-color fluorescent staining of spleen cells clearly revealed that all CD11clow Ly-6Chigh CD45R (B220)+ PDCs are PDCA-1+ and that PDCA-1 expression is restricted to PDCs. |
| Immunogen | n/a |
| Other Names | BST2, Bst-2, C87040, mPDCA-1, DAMP-1, GREG |
| Gene, Accession # | Gene ID: 69550 |
| Catalog # | 130-102-293 |
| Price | $72 |
| Order / More Info | CD317 (PDCA-1), Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Julian, M. W. et al. (2012) Mitochondrial transcription factor A serves as a danger signal by augmenting plasmacytoid dendritic cell responses to DNA. J Immunol 189 (1): 433-443. | Matsui, H. et al. (2012) Mechanism of action of inhibition of allergic immune responses by a novel antedrug TLR7 agonist. J Immunol 189 (11): 5194-5205. | Shen, H. and Iwasaki, A. (2006) A crucial role for plasmacytoid dendritic cells in antiviral protection by CpG ODN-based vaginal microbicide. J. Clin. Invest. 116: 2237-2243. | Krug, A. et al. (2004) TLR9-dependent recognition of MCMV by IPC and DC generates coordinated cytokine responses that activate antiviral NK cell function. Immunity 21: 107-119. | Colonna, M. et al. (2004) Plasmacytoid dendritic cells in immunity. Nat Immunol 5: 1219-1226. | Kuwajima, S. et al. (2006) Interleukin 15-dependent crosstalk between conventional and plasmacytoid dendritic cells is essential for CpG-induced immune activation. Nat Immunol 7: 740-746. | Yoo, J. K. et al. (2010) Identification of a novel antigen-presenting cell population modulating antiinfluenza type 2 immunity. J. Exp. Med. 207 (7): 1435-1451. | Yoneyama, H. et al. (2005) Plasmacytoid DCs help lymph node DCs to induce anti-HSV CTLs. J. Exp. Med. 202 (3): 425-435. | Fallarino, F. et al. (2005) Ligand and cytokine dependence of the immunosuppressive pathway of tryptophan catabolism in plasmacytoid dendritic cells. Int. Immunol. 17 (11): 1429-1438. | Xu, H. et al. (2007) Identification of novel dendritic cell populations in normal mouse retina. Invest. Ophthalmol. Vis. Sci. 48 (4): 1701-1710. | Fischer, J. et al. (2004) mPDCA-1: A presumably novel antigen exclusively expressed by murine plasmacytoid dendritic cells. MACS&more 8 (1): 13-15. | Daito, H. et al. (2011) Mycobacterial hypersensitivity pneumonitis requires TLR9-MyD88 in lung CD11b+ CD11c+ cells. Eur. Respir. J. 38 (3): 688-701. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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