TCR Vα11.1, 11.2, Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | TCR Vα11.1, 11.2, Mouse |
| Clone | REA464 |
| Host Species | Recombinant Human |
| Reactive Species | mouse |
| Isotype | IgG1 |
| Format | biotin conjugate |
| Size | 30 µg in 1 mL |
| Concentration | 1:10 |
| Applications | Flow cytometry, MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | TCR Vα11.1, 11.2 Antibody, anti-mouse, Biotin, REAfinity™. Clone REA464 recognizes the mouse V alpha 11.1 and 11.2 T cell receptor (TCR Vα11.1, 11.2) of mice having the b (e.g., C57BL/6) and d (e.g., DBA/1, DBA/2, NZW) haplotypes, but not with the strains having the a (Balb/c) or c (e.g., SJL, NOD) haplotype. The TCR is responsible for recognizing antigens bound to major histocompatibility complex (MHC) molecules. It is a disulfide-linked membrane-anchored heterodimeric glycoprotein normally consisting of the highly variable alpha and beta chains expressed as part of a complex with the invariant CD3 chain molecules. TCR Vα elements are expressed preferentially in CD4 or CD8 subsets in a manner that is largely independent of the MHC haplotype. It is likely that the Vα elements interact preferentially with conserved regions of class I or class II molecules. | Additional information: Clone REA464 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | TCRA, AV11S2, Va11.2, Va11.2b, AV11S1, Va11.1, Va11.1b, TCR-Va11.1, 11.2 |
| Gene, Accession # | Gene ID: 110584, 110583, 21473 |
| Catalog # | 130-106-939 |
| Price | $57 |
| Order / More Info | TCR Vα11.1, 11.2, Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Osman, G. E. et al. (1998) Expression of a type II collagen-specific TCR transgene accelerates the onset of arthritis in mice. Int. Immunol. 10 (11): 1613-1622. | Nakajima, P. B. et al. (1992) Chromosome 14 in B10.A(18R) mice is recombinant and includes Tcra-Va alleles. Immunogenetics 35 (3): 190-198. | Osman, G. E. et al. (1999) T-cell receptor vbeta deletion and valpha polymorphism are responsible for the resistance of SWR mouse to arthritis induction. Immunogenetics 49 (9): 764-772. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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