CD124 (IL-4Rα), Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | CD124 (IL-4Rα), Mouse |
| Clone | REA235 |
| Host Species | Recombinant Human |
| Reactive Species | mouse |
| Isotype | IgG1 |
| Format | PE-Vio 770 conjugate |
| Size | 30 µg in 200 µL |
| Concentration | 1:50 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD124 (IL-4Rα) Antibody, anti-mouse, PE-Vio® 770, REAfinity™. Clone REA235 recognizes the CD124 antigen, a 140 kDa transmembrane glycoprotein which is also known as interleukin-4 receptor subunit alpha (IL-4Rα). CD124 is expressed on both B and T lymphocytes, and on cells of several other hematopoietic lineages, including mast cell, macrophage, and undifferentiated hematopoietic cell lines. CD124 is a receptor for both IL-4 and IL-13. The functional IL-4 receptor is formed by initial binding of IL-4 to IL-4R. Subsequent recruitment to the complex of the common γ chain, in immune cells, creates a type I receptor and, in non-immune cells, of CD213a1 (IL-13RA1) forms a type II receptor. IL-4R can also interact with the IL-13/CD213a1 complex to form a similar type II receptor. The type I IL-4 receptor complex specifically binds IL-4 whereas the type II IL-4R binds either IL-4 or IL-13. The IL-4/IL-13 responses are involved in regulating the IgE production in B cells and in alternative activation of macrophages. Binding of IL-4 to CD124 on T cells promotes differentiation of T?2 cells. Clone REA235 blocks the binding of IL-4 to cells and also recognizes the soluble truncated form of CD124. | Additional information: Clone REA235 displays negligible binding to Fc receptors. | |
| Immunogen | n/a |
| Other Names | IL4RA, IL-4R |
| Gene, Accession # | Gene ID: 16190 |
| Catalog # | 130-127-890 |
| Price | $128 |
| Order / More Info | CD124 (IL-4Rα), Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Blum, H. et al. (1996) Two distinct stimulus-dependent pathways lead to production of soluble murine interleukin-4 receptor. J Immunol 157 (5): 1846-1853. | Ohara, J. et al. (1987) Receptors for B-cell stimulatory factor-1 expressed on cells of haematopoietic lineage. Nature 325 (6104): 537-540. | Nelms, K. et al. (1999) The IL-4 receptor: signaling mechanisms and biologic functions. Annu. Rev. Immunol. 17: 701-738. | Mosley, B. et al. (1989) The murine interleukin-4 receptor: molecular cloning and characterization of secreted and membrane bound forms. Cell 59 (2): 335-348. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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