CD196 (CCR6), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | CD196 (CCR6), Human |
| Clone | REA190 |
| Host Species | Recombinant Human |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | PE-Vio 770 conjugate |
| Size | 100 tests in 200 µL |
| Concentration | 1:50 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD196 (CCR6) Antibody, anti-human, PE-Vio® 770, REAfinity™. Clone REA190 recognizes CD196 (CCR6), a seven transmembrane G protein-coupled receptor, which belongs to the family of beta chemokine receptors. Expression of CD196 is found on T cells, naive and memory B cells, and immature dendritic cells (DCs). CD196 selectivly binds chemokine MIP-3α/CCL20, which is secreted by a number of cells and tissues. In addition, members of a family of small cationic antimicrobial peptides, such as human β-defensins (hBD)-1 and -2, which are released by epithelial cells in response to microbial invasion or proinflammatory stimuli, are also shown to bind to CCR6. This interaction induce chemotaxis in immature dendritic cells and memory T cells. | Additional information: Clone REA190 displays negligible binding to Fc receptors. | |
| Immunogen | n/a |
| Other Names | CCR6, BN-1, CKRL3, CMKBR6, DCR2, DRY6, GPR29, GPRCY4, STRL22 |
| Gene, Accession # | Gene ID: 1235 |
| Catalog # | 130-117-685 |
| Price | $365 |
| Order / More Info | CD196 (CCR6), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Yang, D. et al. (1999) Beta-defensins: Linking innate and adaptive immunity through dendritic and T cell CCR6. Science 286 (5439): 525-528. | Bergmann-Leitner, E. et al. (2018) Identification of immune signatures of novel adjuvant formulations using machine learning. Sci Rep 8 (1): 17508. | Dorraji, E. et al. (2018) Mesenchymal stem cells and T cells in the formation of tertiary lymphoid structures in lupus nephritis. Sci Rep: 7861. | Farooq, F. et al. (2016) Circulating follicular T helper cells and cytokine profile in humans following vaccination with the rVSV-ZEBOV Ebola vaccine. Sci Rep 6: 27944. | Schutyser, E. et al. (2003) The CC chemokine CCL20 and its receptor CCR6. Cytokine Growth Factor Rev. 14 (5): 409-426. | Armas-Gonzalez, E. et al. (2018) Role of CXCL13 and CCL20 in the recruitment of B cells to inflammatory foci in chronic arthritis. Arthritis Res. Ther. 20 (1): 114. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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