CD243 (ABCB1), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | CD243 (ABCB1), Human |
| Clone | REA495 |
| Host Species | Recombinant Human |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | phycoerythrin (PE) conjugate |
| Size | 30 tests in 60 µL |
| Concentration | 1:50 |
| Applications | Flow cytometry, MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD243 (ABCB1) Antibody, anti-human, PE, REAfinity™. Clone REA495 recognizes the human CD243 antigen, a multi-pass membrane protein which is also known as multidrug resistance protein 1 (MDR1), ATP-binding cassette sub-family B member 1 (ABCB1), or P-glycoprotein 1. CD243 is a member of the ATP-binding cassette (ABC) transporter superfamily and plays an important role in the development of multidrug resistance (MDR) in cancer cells. This transporter utilizes energy from ATP hydrolysis for the efflux of a variety of chemically dissimilar amphipathic compounds, including anticancer drugs. CD243 is extensively distributed and expressed in the intestinal epithelium, in liver cells, in the cells of the proximal tubule of the kidney and in the capillary endothelial cells composing the blood-brain barrier and blood-testis barrier. It is also expressed on hematopoietic stem cells, T cells, B cells, and NK cells as well as on many multidrug resistant neoplastic cells. | Additional information: Clone REA495 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | ABCB1, ABC20, CLCS, GP170, MDR-1, P-GP, PGY1 |
| Gene, Accession # | Gene ID: 5243 |
| Catalog # | 130-124-449 |
| Price | $119 |
| Order / More Info | CD243 (ABCB1), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Chen, C. J. et al. (1986) Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells. Cell 47 (7): 381-389. | Yao, W. et al. (2014) CD243 gene polymorphism significantly associated with breast cancer susceptibility. Tumour Biol 35 (8): 8017-8022. | Brambila-Tapia, A. J. (2013) MDR1 (ABCB1) polymorphisms: functional effects and clinical implications. Rev Invest Clin 65 (5): 445-454. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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