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Antigenic Specificity | CD68, Mouse |
Clone | REA835 |
Host Species | Recombinant Human |
Reactive Species | mouse |
Isotype | IgG1 |
Format | biotin conjugate |
Size | 150 µg in 1 mL |
Concentration | 1:50 |
Applications | Mass cytometry |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | CD68 Antibody, anti-mouse, Biotin, REAfinity™. Clone REA835 recognizes mouse CD68 antigen, also known as macrosialin, which is a heavily glycosylated type I transmembrane protein of the lysosomal-associated membrane protein (LAMP) family. It is expressed on tissue macrophages, Langerhans cells, and at a low density on dendritic cells. Murine CD68 is predominantly intracellular but it is reported that 10-15% of CD68 is expressed on the cell surface as well. Macrosialin functions as a macrophage receptor for oxidized low density lipoprotein. | Additional information: Clone REA835 displays negligible binding to Fc receptors. |
Immunogen | n/a |
Other Names | Lamp4, SCARD1, gp110, macrosialin |
Gene, Accession # | Gene ID: 12514 |
Catalog # | 130-112-665 |
Price | $202 |
Order / More Info | CD68, Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG |
Product Specific References | Smith, M. J. et al. (1987) Differential expression of murine macrophage surface glycoprotein antigens in intracellular membranes. J. Cell. Sci. 87: 113-119. | Ramprasad, M. P. et al. (1996) Cell surface expression of mouse macrosialin and human CD68 and their role as macrophage receptors for oxidized low density lipoprotein. Proc. Natl. Acad. Sci. U.S.A. 93: 14833-14838. | Kurushima, H. et al. (2000) Surface expression and rapid internalization of macrosialin (mouse CD68) on elicited mouse peritoneal macrophages. J. Leukoc. Biol. 67: 104-108. |